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Tuesday, 04.09.2012
The good clinical practice: useful case report
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Three tumors in a young woman with Cushing‘s syndrome
L. Hendriks, R. Mostard, E. van Haren, L. van de Winkel, P. van Battum, W. Schreurs (Heerlen, Netherlands)
Source:
Annual Congress 2012 - The good clinical practice: useful case report
Session:
The good clinical practice: useful case report
Session type:
Thematic Poster Session
Number:
3514
Disease area:
Thoracic oncology
Abstract
Case: A 38-year old female with no relevant medical history was referred to internal medicine with clinical features comparable with Cushing‘s syndrome. Laboratory results suggested ectopic adrenocorticotropic hormone (ACTH) production. The pituitary gland had a normal aspect on magnetic resonance imaging but computed tomography of the chest showed a smooth, oval mass in the posterior mediastinum and a nodule in the left upper lobe. Differential diagnosis consisted of carcinoid, small cell lung cancer or neurogenic tumor. Bronchoscopy showed no endobronchial lesions but both lesions could not be reached with fluoroscopic guidance. On
18
F-deoxyglucose positron emission tomography (
18
FDG-PET) increased
18
FDG uptake was seen in the mediastinal mass and in the right gluteal region, but not in the left upper lobe. Somatostatin scintigraphy showed uptake in the left upper lobe, but not in the other masses. Histological biopsy of the gluteal mass showed a desmoid type fibromatosis. Wedge resection with peroperative frozen section of the left upper lobe mass was performed and a typical carcinoid (T1a) was found. For treatment and staging resection of the left upper lobe with mediastinal lymph node sampling and resection of the mediastinal mass followed in the same session. The resections were complete but one lymph node (N2) was positive for carcinoid metastases. The mediastinal mass appeared to be a schwannoma.
Conclusion: Cushing‘s syndrome caused by ectopic ACTH in a T1aN2M0 typical carcinoid. Furthermore, the two PET-positive lesions appeared to be a schwannoma and a desmoid type fibromatosis. This case stresses the importance to link presenting condition with imaging features and to obtain histological confirmation.
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Citations should be made in the following way:
L. Hendriks, R. Mostard, E. van Haren, L. van de Winkel, P. van Battum, W. Schreurs (Heerlen, Netherlands). Three tumors in a young woman with Cushing‘s syndrome. Eur Respir J 2012; 40: Suppl. 56, 3514
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