Source: Annual Congress 2012 - Exercise capacity: from elite athletes to severe impairment

Abstract

Background: Muscle oxygenation correlates with systemic oxygen uptake (VO₂) in normal subjects, however whether this relationship exists chronic respiratory failure (CRF) patients remains unclear.
Objectives:The purpose of this study was to investigate the influence of skeletal muscle oxygenation on VO₂ during exercise in CRF patients.
Methods: Ten chronic obstructive pulmonary disease and two sequelae of pulmonary tuberculosis patients performed an incremental cycle ergometer exercise test. We measured ventilation, pulmonary gas exchange and SaO₂. We also measured tissue oxygen saturation (StO₂) in the vastus lateralis with continuous-wave near-infrared spectroscopy. We calculated the muscle oxygen extraction rate (MOER) based on SaO₂ and StO₂. In addition, we performed regression analysis to examine the relationships between the VO₂ obtained during exercise testing and the mean values of SaO₂, StO₂, heart rate (HR), and MOER for each 30-second interval of the tests. Finally, we analysed the relationships between the peak value of oxygen uptake (VO_2peak) and the slopes of HR/VO₂, SaO₂/VO₂, StO2/VO₂, and MOER/VO₂.
Results: With the increasing exercise intensity, many subjects showed a gradual decrease in StO₂ and SaO₂, but a gradual increase in HR and MOER. VO₂ was negatively correlated with StO₂ and SaO₂, and was positively correlated with HR and MOER. However, VO_2peak was not correlated with any of the slopes.
Conclusions: VO₂ is highly influenced by oxygen utilization in exercising muscles, as well as by blood oxygenation levels and cardiac function. However, the impact of skeletal muscle utilization during exercise on VO_2peak varied greatly among the patients.

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Citations should be made in the following way:
K. Tabira, J. Horie, H. Fujii, T. Aida (Kitakatsuragi-gun, Kobe, Osaka, Japan). Skeletal muscle oxygenation during exercise in patients with chronic respiratory failure. Eur Respir J 2012; 40: Suppl. 56, 846

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