Longitudinal analysis of airway epithelium of COPD subjects reveals unique inflammatory gene networks up-regulated over time

S. Sridhar, J.S. Fine, C.S. Stevenson, H. Bitter, A.E. Tilley, B.G. Harvey, R. Kaner, M.R. Staudt, J. Fuller, J. Salit, N. Hackett, H. Hilton, S. Pillai, G. Wolff, S. Visvanathan, R.G. Crystal (Nutley, New York, Ridgefield, United States Of America)

Source: Annual Congress 2012 - COPD inflammation and genes
Session: COPD inflammation and genes
Session type: Poster Discussion
Number: 4800
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Sridhar, J.S. Fine, C.S. Stevenson, H. Bitter, A.E. Tilley, B.G. Harvey, R. Kaner, M.R. Staudt, J. Fuller, J. Salit, N. Hackett, H. Hilton, S. Pillai, G. Wolff, S. Visvanathan, R.G. Crystal (Nutley, New York, Ridgefield, United States Of America). Longitudinal analysis of airway epithelium of COPD subjects reveals unique inflammatory gene networks up-regulated over time. Eur Respir J 2012; 40: Suppl. 56, 4800

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A nasal gene expression profile differentiates individuals with and without COPD and overlaps bronchial gene expression
Source: International Congress 2017 – Rare and common genetic variants of common and rare airway diseases
Year: 2017


Differential gene expression in primary bronchial epithelial cells from COPD patients and control subjects. Evaluation by means of a cDNA array for cytokines and cytokine related genes
Source: Eur Respir J 2002; 20: Suppl. 38, 483s
Year: 2002

Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells
Source: ERJ Open Res, 6 (4) 00656-2020; 10.1183/23120541.00656-2020
Year: 2020



Gene expression signatures in airway and nasal epithelium of COPD: linking endotypes to clinical outcomes
Source: International Congress 2017 – Heterogeneity in COPD inflammation: implications for therapy and clinical outcomes
Year: 2017


Human bronchial epithelial cells from patients with asthma have an altered gene expression profile
Source: ERJ Open Res, 8 (1) 00625-2021; 10.1183/23120541.00625-2021
Year: 2022



Distinct epithelial phenotypes in child allergic respiratory disease are revealed by gene expression profiling
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009

Meta-analysis of airway epithelium gene expression in asthma
Source: Eur Respir J, 51 (5) 1701962; 10.1183/13993003.01962-2017
Year: 2018



PP105 – Single-cell transcriptome analysis reveals an anomalous epithelial variation and ectopic inflammatory response in COPD
Source: ERS Lung Science Conference 2021
Year: 2021

Differential bronchial epithelial gene expression in COPD versus controls
Source: International Congress 2016 – Molecular targets in pulmonary disease
Year: 2016

Identification of transcripts overexpressed during airway epithelium differentiation
Source: Eur Respir J 2008; 32: 121-128
Year: 2008



Global gene expression analyses highlight the role of plasma membrane remodeling as a molecular functions of airway epithelium in response to interleukin-13 treatment
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015


Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD
Source: ERJ Open Res, 4 (4) 00031-2018; 10.1183/23120541.00031-2018
Year: 2018



Infectional factors influences on expressiveness of inflammatory process and structural changes in bronchial mucosa at COPD patients
Source: Eur Respir J 2006; 28: Suppl. 50, 576s
Year: 2006

Transcriptomic profiling of alveolar type 2 cells from mice expressing an ILD associated SFTPCI73T mutation supports their role in inflammatory cell recruitment and fibrotic lung remodeling.
Source: International Congress 2018 – Pulmonary fibrosis: from models to patients
Year: 2018

Consensus network analysis reveals pathways associated with lung function decline in both COPD and IPF
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

Differential mast cell activation by transcriptomic signature analysis in the U-BIOPRED severe asthma cohort
Source: Virtual Congress 2020 – Novel methods, diagnostics and biomarkers of chronic lung diseases
Year: 2020


Expression of cholinergic system components in the airway epithelium of COPD patients
Source: Annual Congress 2008 - Basic science in asthma and COPD
Year: 2008


COPD phenotypes revealed by the integrated sputum microbiome and proteome analysis in COPDMAP cohort
Source: International Congress 2019 – Host-microbe interactions in lung disease and exacerbations
Year: 2019

Wnt/ß-catenin signalling is upregulated in the COPD bronchial epithelium.
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019


Microarray gene expression profiles in lung tissue of COPD patients
Source: Eur Respir J 2007; 30: Suppl. 51, 537s
Year: 2007