Source: Annual Congress 2012 - Lung transplantation: studies in candidates and recipients

Abstract

Background: Only few studies reported findings on CO₂ rebreathing in long-term bilateral lung transplant recipients. Bilateral lung transplantation causes denervation of the donor lung. This might have an impact on control of breathing as measured by the hypercapnic ventilatory response (HCVR). The influence of gender on HCVR and the relation to exercise capacity is unknown yet.
Objectives: To study HCVR and the relation to exercise capacity after bilateral lung transplantation.
Methods and patients: Minute ventilation, respiratory rate and HCRV were studied in 24 bilateral lung transplant recipients (12 male). HCVR was measured according to the Read protocol. Exercise testing was performed to evaluate the maximum level of workload. This was expressed as percentage of the corresponding reference value.
Results: Age and body mass index (BMI) of men and women were similar (age: 56 ± 9 years vs. 54 ± 9 years (n.s.), BMI: 26 ± 3 kg/m² vs. 25 ± 6 kg/m² (n.s.)). Post-transplant period ranged from 6 months to 9 years. HCVR in lung transplant recipients was 1.71 ± 1.25 l/min/mmHg in men and 0.95 ± 0.38 l/min/mmHg in women (p<0.05). In healthy controls HCVR at our laboratory were 2.02 ± 0.77 l/min/mmHg for men and 1.51 ± 0.64 l/min/mmHg for women (p<0.05). After adjustment for FEV1 and gender in multivariate analysis we found a statistically significant correlation between the exercise capacity and HCVR.
Conclusion: There is a remarkable difference in ventilatory response to carbon dioxide between male and female bilateral lung transplant recipients, suggesting a role for denervation of the lung in the impairment of exercise capacity after bilateral lung transplantation.

Rating:

Share or cite this content

Citations should be made in the following way:
M. Weidmann, B.E. Kleibrink, T. Rabis, G. Weinreich, M. Kamler, H. Teschler, U. Sommerwerck (Essen, Germany). Low hypercapnic ventilatory response in long-term lung transplant recipients predicts exercise impairment. Eur Respir J 2012; 40: Suppl. 56, 1485

Member's Comments

No comment yet.

Related content which might interest you: Reduced ventilatory efficiency during exercise in lung transplant recipients Source: Virtual Congress 2021 – Optimising outcomes of lung transplantation: how to move forward? Year: 2021 Baseline lung function and ventilatory response to exercise in patients with chronic heart failure Source: Annual Congress 2008 - Pulmonary mechanics and gas exchange Year: 2008 Decreased hypercapnic ventilatory response in long-term lung transplant recipients Source: Annual Congress 2013 –Back to basics: the upper airway and physiology in sleep disordered breathing Year: 2013 Hyperinflation correlates with poor exercise tolerance in recipients with advanced chronic lung allograft dysfunction Source: Annual Congress 2012 - Lung transplantation: studies in candidates and recipients Year: 2012 Physiologic and lung function outcomes of home mechanical ventilation in chronic hypercapnic COPD patients Source: Virtual Congress 2020 – Home non-invasive ventilation: (long-term) effects and prognosis Year: 2020 The effect of renal failure on the success of noninvasive ventilation in COPD patients with hypercapnic respiratory failure Source: Annual Congress 2010 - Noninvasive ventilation in the acute patient: outcome and pathophysiology Year: 2010 Long-term changes in lung function, dyspnea and exercise capacity in COPD patients Source: Eur Respir J 2002; 20: Suppl. 38, 490s Year: 2002 Ventilatory response to exercise in patients with COPD Source: Eur Respir J 2005; 26: Suppl. 49, 108s Year: 2005 Effect of exercise training on ventilation in patients with COPD or chronic heart failure Source: Annual Congress 2012 - Exercise capacity: from elite athletes to severe impairment Year: 2012 Effects of hyperoxia and helium-hyperoxia on the cardiocirculatory responses to incremental exercise in hypoxaemic patients with advanced COPD Source: Annual Congress 2011 - Cardio-pulmonary interactions Year: 2011 Determinants and consequences of exercise ventilatory inefficiency in patients with COPD-heart failure overlap Source: International Congress 2017 – Exercise testing in cardiorespiratory diseases Year: 2017 The effects of short-term nocturnal non-invasive ventilation (NIV) on respiratory muscle functional capacity in COPD patients with chronic hypercapnic respiratory failure (CHRF) Source: Virtual Congress 2021 – New insights into the pathophysiology and prognosis of COPD Year: 2021 Effect of pulmonary rehabilitation on exercise tolerance and functional class in patients with COPD and heart failure Source: Virtual Congress 2020 – The multiple facets of pulmonary rehabilitation and chronic respiratory care Year: 2020 Peak exercise lung function in chronic heart failure Source: Eur Respir J 2006; 28: Suppl. 50, 175s Year: 2006 Induced acute metabolic acidosis improves alveolar ventilation in chronic hypercapnic COPD patients Source: Eur Respir J 2005; 26: Suppl. 49, 517s Year: 2005 Effects of eight weeks exercise training on functional capacity, ventilatory efficiency and quality of life in patients with chronic heart failure Source: Eur Respir J 2002; 20: Suppl. 38, 287s Year: 2002 ACE-inhibition improves peak exercise oxygen uptake and ventilation in COPD: an effect unrelated to pulmonary function Source: Eur Respir J 2003; 22: Suppl. 45, 205s Year: 2003 Heart failure impairs cerebral oxygenation during exercise in patients with COPD Source: Eur Respir J 2013; 42: 1423-1426 Year: 2013 Prolonged mechanical ventilation negatively affects survival and functional outcome in lung transplant recipients Source: International Congress 2015 – Outcomes of lung transplantation Year: 2015 Association of impaired ventilatory efficiency with Chyene-Stokes respiration in patients with chronic heart failure Source: Eur Respir J 2002; 20: Suppl. 38, 292s Year: 2002