Source: Annual Congress 2012 - Lung transplantation: studies in candidates and recipients
Disease area: Sleep and breathing disorders

Abstract

Background: To date, only a few studies with small sample size analysed sleep-disordered breathing (SDB) in lung transplant recipients (LTX). Therefore, little is known on the prevalence of SDB and the impact of this disorder on morbidity and mortality.
Objective: Our ongoing prospective study aims to determine the prevalence of SDB and the consequences of this disorder in LTX.
Patients and Methods: Between March 2011 and February 2012 we included 28 clinically stable lung transplant recipients (16 men, time range after LTX 6 months to 9 years). Full polysomnography (PSG) was performed to investigate sleep characteristics and SDB. An apnea-hypopnea index (AHI) ≥10/h was used as definition for SDB. Daytime sleepiness was measured by the Epworth Sleepiness Scale (ESS) questionnaire.
Results: Indications for LTX were: 15 COPD, 11 idiopathic pulmonary fibrosis, 1 alpha-1 antitrypsin deficiency, 1 pulmonary hypertension. Age was 54.2±8.3 years, body mass index 25.5±4.0 kg/m² and FEV1 69±31% predicted. The prevalence of SDB was 57% (50% obstructive sleep apnea, 7% central sleep apnea). Total sleep time (TST) was 372±91 min in the SDB group and 355±93 min in the non-SDB group (n.s). Sleep efficiency was 68.7±17.1% in the SDB group and 67.1±19.9% in the non-SDB group (n.s). ESS was 4.5±4.1 in the SDB group and 3.6±3.2 in the non-SDB group (n.s).
Conclusions: The prevalence of SDB is high in lung transplant recipients, and sleep quality is equally poor for those with and without SDB compared to the general population. Interestingly, neither the occurrence of SDB nor the quality of sleep was associated with symptoms of sleepiness as measured by ESS.

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U. Sommerwerck, T. Rabis, B.E. Kleibrink, N. Langguth, Y. Wang, I. Moraides, S. Werther, M. Kamler, H. Teschler, G. Weinreich (Essen, Germany). Sleep quality and sleep-disordered breathing in lung transplant recipients. Eur Respir J 2012; 40: Suppl. 56, 1486

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