Source: Annual Congress 2012 - Prognostic indices in respiratory infections
Disease area: Paediatric lung diseases, Respiratory infections

Abstract

Background: Bronchiectasis (B.) is induced by different mechanisms, one of these is primary ciliary dyskinesia (PCD). Genetic aberrations lead to a lack of mucociliary clearance. The bacterial biofilm in B. of patients with PCD in comparison to CF was studied by fluorescence in situ hybridisation (FISH).
Material and Methods: An explant and 2 middle lobe resections of 3 patients (age between 5 and 50 years) were investigated using conventional histology. Diagnosis of PCD was confirmed by transmission electron microscopy. For comparison 10 explants of CF patients were available. Of all cases, at least 2 locations were studied by FISH using a pan-bacterial and a Pseudomonas (Ps.) specific probe.
Results: Histology revealed typical B. In all 3 PCD cases no bacterial biofilms were detected by FISH, although in at least one case Ps. was detected by culture previously. In comparison all CF cases showed colonization with Ps.
Conclusions: Significant differences exist concerning bacterial biofilms in PCD versus CF. This might be of relevance for the clinical practise.

Rating:

Share or cite this content

Citations should be made in the following way:
D. Theegarten, J. Kikhney, A. Petrich, U. Sommerwerck, S. Welter, O. Anhenn, A. Moter (Essen, Berlin, Germany). Bacterial biofilms in bronchiectasis of primary ciliary dyskinesia (PCD) in comparison with cystic fibrosis (CF). Eur Respir J 2012; 40: Suppl. 56, 2527

Member's Comments

No comment yet.

Related content which might interest you: Function of ciliary epithelium in the patients with cystic fibrosis (CF) with chronic Ps.aeruginosa infection and without Ps.aeruginosa Source: Eur Respir J 2001; 18: Suppl. 33, 125s Year: 2001 Systematic review of lung clearance index (LCI) in non-cystic fibrosis (CF), non-primary ciliary dyskinesia (PCD) bronchiectasis (Bx) Source: Virtual Congress 2021 – Bronchiectasis Year: 2021 Differences in airway inflammation between children with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) Source: International Congress 2014 – Cystic fibrosis: genotypes, inflammation and microbiology Year: 2014 Primary ciliary dyskinesia and mild cystic fibrosis: lung structure and function similarities. Source: International Congress 2017 – Paediatric bronchology in clinical practice Year: 2017 Monitoring small airways disease (SAD) in cystic fibrosis (CF) Source: Annual Congress 2011 - Monitoring with lung function tests in airway diseases Year: 2011 Evolution of the infectious disease in cystic fibrosis (CF) Source: Research Seminar 2008 - Host-pathogen interactions in the lung: implications for treatment of respiratory infections and inflammatory lung diseases Year: 2008 Cough detection in cystic fibrosis, primary ciliary dyskinesia and health Source: International Congress 2016 – Non-inflammatory assessment of airway disorders Year: 2016 Primary ciliary dyskinesia and non Cystic fibrosis bronchiectasis Source: ERS Skills Course 2016 Year: 2016 Functional dead space in children with cystic fibrosis or primary ciliary dyskinesia. Source: International Congress 2018 – Assessing pathophysiology in children Year: 2018 Chronic rhinosinusitis in non-cystic fibrosis bronchiectasis and primary ciliary dyskinesia Source: Eur Respir Monogr 2017; 76: 148-161 Year: 2017 Macrolides in cystic fibrosis (CF); clinical experience Source: Eur Respir J 2004; 24: Suppl. 48, 615s Year: 2004 Effect of recurrent growth of aspergillus on lung function in paediatric population with cystic fibrosis (CF) Source: Annual Congress 2011 - Cystic fibrosis: new basic, clinical and bacteriological knowledge Year: 2011 Relationship between nasal potential difference (NPD) and respiratory function in cystic fibrosis (CF) patients Source: Eur Respir J 2001; 18: Suppl. 33, 125s Year: 2001 Nasal cavity inflammation in patients with primary ciliary dyskinesia (PCD) is associated with bacterial infection Source: International Congress 2017 – Paediatric respiratory infections and immunity Year: 2017 Primary ciliary dyskinesia and non-CF bronchiectasis Source: ERS Skills Course 2017 - Summer school of paediatric respiratory medicine Year: 2017 Primary ciliary dyskinesia and non-CF bronchiectasis Source: ERS Course 2019 - Summer school of paediatric respiratory medicine 2019 Year: 2019 Primary ciliary dyskinesia and non-CF bronchiectasis Source: ERS Course 2018 - Summer school of paediatric respiratory medicine Year: 2018 Molecular detection of complex microbial communities in sputa of patients with cystic fibrosis and non cystic fibrosis bronchiectasis Source: Annual Congress 2010 - Cystic fibrosis: lung disease infection and more Year: 2010 Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia Source: Eur Respir J 2016; 47: 829-836 Year: 2016 Prevalence of renal impairment in an adult cystic fibrosis (CF) centre Source: Eur Respir J 2005; 26: Suppl. 49, 622s Year: 2005