Source: Annual Congress 2012 - Various issues in clinical physiology
Disease area: Airway diseases

Abstract

Introduction: Allergy in asthmatics is accompanied with the increase of exhaled breath temperature. The correlation of this parameter with airway patency is known little about.
Aim: To study the correlation between bronchi patency and exhaled breath temperature in patients with bronchial asthma.
Methods: The exhaled breath temperature (TºC) during quiet breathing using a device «X-halo» (Delmedica Investments Pte Ltd), lung function (FEV₁, FEV₁/FVC) and the level of hydrogen peroxide (H₂O₂) in exhaled breath condensate (EBC) were studied in 82 patients with bronchial asthma (the mean age 35.0±1.1 years).
Results: The patients were divided into two groups according to the presence of airway patency impairment or its absence (FEV₁ 80.8±2.69 and 108.3±2.09%; p<0.001; FEV₁/FVC 68.3±1.37 and 77.8±1.23%; p<0.001, respectively). In the group of patients with airway patency impairment there were a significant decrease of exhaled breath temperature (34.0±0.14°C) and the increase of H₂O₂ level (1.18±0.08nmole/ml) in EBC in comparison with the group of patients without lung function changes (34.5±0.14°C; p<0.05; 0.89±0.08 nmole/ml; p<0.05, respectively). There was found the correlation between the exhaled breath temperature and FEV₁ (r=0.22; p<0.05) and the bronchodilation response to β₂-agonist (ΔFEV₁, r=-0.41; p<0.01), as well as between the level of H₂O₂ in EBC and FEV₁ (r=-0.64; p<0.01).
Conclusion: The decrease of exhaled breath temperature in asthmatics is associated with the disturbance of bronchial patency and reversibility of bronchial obstruction.

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Citations should be made in the following way:
J. M. Perelman, A. G. Prikhodko, N. M. Smirnova (Blagoveschensk, Russian Federation). Disturbance of airway patency is accompanied by a decrease of exhaled breath temperature in asthmatics. Eur Respir J 2012; 40: Suppl. 56, 3792

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