Source: Annual Congress 2012 - Metabolic and cardiovascular consequences of OSA II
Disease area: Sleep and breathing disorders

Abstract

Background: Obstructive sleep apnea (OSA) is usually associated with cardiovascular diseases and also metabolic syndrome including diabetes, lipid metabolism
Objectives: The aim of the study was to evaluate the prevalence of hypertension (HT), diabetes mellitus (DM), hyperlipidemia (HL), and cardiovascular diseases (CVD) in the Japanease with proven OSA.
Methods: We retrospectively analyzed the data accrued in 1,000 patients who underwent the first time polysomnography (PSG) in our hospital from June 2001. They were 836 males and 164 females, the mean age of 54.5 years, the mean body mass index (BMI) of 26.0kg/m², and the mean apnea-hypopnea index (AHI) of 38.0. We examined the association between OSA and cardiovascular diseases, metabolic syndrome.
Results: 938 between 1,000 patients were diagnosed with OSA. 41.2% of patients with OSA had HT compared with 21.0% of patients with non-OSA. And the OSA patients had 18.6% of DM, 45.3% of HL, 25.2% of liver dysfunction, 7.6% of CVD, comparing with 6.5% of DM, 29.0% of HL, 19.4% of liver dysfunction, and 3.3% of CVD in the non-OSA patients. In addition, the OSA patients treated with continuous positive airway pressure (CPAP) had 69.7% of HT, 23.8% of DM, 77.1% of HL, 40.7% of Liver dysfunction, and 21.2% of CVD. The blood pressure was reduced significantly by CPAP.
Conclusions: The risk of HT, DM, and CVD in OSA patients was almost two times more than those of non-OSA patients. We suggested that the OSA patients with higher severity OSA patients tended with a higher rate of complications.

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Citations should be made in the following way:
A. Matsuo, M. Kosaka, N. Kobayashi, T. Horiuchi, T. Agatsuma, A. Ushiki, S. Kanda, K. Keishi (Nagano, Matsumoto, Japan). Association of cardiovascular diseases, metabolic syndrome and obstructive sleep apnea: Data from 1,000 Japanease PSG cases. Eur Respir J 2012; 40: Suppl. 56, 3867

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