EPITOME-2: Evaluation of a new formulation of epoprostenol sodium in pulmonary arterial hypertension patients switched from an originally approved formulation

O. Sitbon, M. Delcroix, E. Bergot, A. Boonstra, P. Escribano Subias, N. Galiè, J. Granton, D. Langleben, T. Pfister, J.C. Lemarié, G. Simonneau (Le Kremlin Bicêtre, Caen, Paris, France; Leuven, Belgium; Amsterdam, Netherlands; Madrid, Spain; Bologna, Italy; Toronto, Montreal, Canada; Allschwil, Switzerland)

Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Session: Pulmonary circulation: clinical PAH, registries and treatments
Session type: Thematic Poster Session
Number: 947
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
O. Sitbon, M. Delcroix, E. Bergot, A. Boonstra, P. Escribano Subias, N. Galiè, J. Granton, D. Langleben, T. Pfister, J.C. Lemarié, G. Simonneau (Le Kremlin Bicêtre, Caen, Paris, France; Leuven, Belgium; Amsterdam, Netherlands; Madrid, Spain; Bologna, Italy; Toronto, Montreal, Canada; Allschwil, Switzerland). EPITOME-2: Evaluation of a new formulation of epoprostenol sodium in pulmonary arterial hypertension patients switched from an originally approved formulation. Eur Respir J 2012; 40: Suppl. 56, 947

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
EPITOME-4, a phase 3b study evaluating a new formulation of epoprostenol sodium in pulmonary arterial hypertension following switch from Flolan®
Source: Annual Congress 2013 –Pulmonary circulation: clinical diagnosis, imaging, biomarkers and treatment
Year: 2013

A clinical comparison of slow- and rapid-escalation treprostinil dosing regimens in patients with pulmonary arterial hypertension (PAH)
Source: Eur Respir J 2003; 22: Suppl. 45, 563s
Year: 2003

Combination therapy in severe pulmonary hypertension with bosentan and treprostinil: successful switch from subcutaneous to intravenous application
Source: Eur Respir J 2006; 28: Suppl. 50, 384s
Year: 2006

Clinical sildenafil use in Belgian patients with pulmonary arterial hypertension (PAH)
Source: Annual Congress 2010 - Pulmonary circulation II
Year: 2010

LTI-201: Evaluation of the hemodynamics and safety of inhaled LIQ861 (treprostinil) in pulmonary arterial hypertension (WHO Group 1) patients
Source: Virtual Congress 2020 – Epidemiology and treatment of pulmonary arterial hypertension
Year: 2020


Long-term safety of a new formulation of epoprostenol in pulmonary arterial hypertension
Source: Annual Congress 2013 –Pulmonary circulation: clinical diagnosis, imaging, biomarkers and treatment
Year: 2013

Selection of the optimal nebulizer for further clinical development of inhaled nebulized nitrite (AIR001) in pulmonary arterial hypertension patients
Source: Annual Congress 2012 - Pulmonary circulation: clinical aspects of PAH, PTE and CTEPH
Year: 2012


Rapid switch from epoprostenol (EPO) to intravenous treprostinil (TRE) in patients with pulmonary arterial hypertension (PAH): safety, efficacy, and treatment satisfaction
Source: Annual Congress 2009 - Pulmonary arterial hypertension
Year: 2009


Safety and efficacy of bosentan in combination with sildenafil in pulmonary arterial hypertension: The COMPASS-3 study
Source: Annual Congress 2011 - Treatments for pulmonary hypertension in human and experimental models
Year: 2011


COPD and concomitant arterial hypertension: The efficacy and safety of slow-release formulation of indapamide
Source: International Congress 2014 – Clinical presentations
Year: 2014


Parenteral treprostinil for significant pulmonary arterial hypertension associated with pulmonary fibrosis: A safety study
Source: Annual Congress 2011 - Treatment of pulmonary hypertension
Year: 2011

Risk assessment and prognosis in patients with pulmonary arterial hypertension receiving intravenous treprostinil
Source: International Congress 2019 – Endpoints and risk assessment of pulmonary arterial hypertension
Year: 2019



Safety and tolerability of rapid dose-titration of subcutaneous (SC) treprostinil in pulmonary arterial hypertension (PAH)
Source: International Congress 2015 – Pulmonary hypertension: novel clinical insights
Year: 2015

Initial combination therapy with epoprostenol and bosentan in severe pulmonary arterial hypertension
Source: Annual Congress 2009 - Pulmonary arterial hypertension
Year: 2009


Rationale and study design of the RESPITE trial: Riociguat clinical effects studied in pulmonary arterial hypertension (PAH) patients with insufficient treatment response to PDE-5 inhibitors (PDE-5i)
Source: International Congress 2015 – Pulmonary hypertension: novel clinical insights
Year: 2015


Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension
Source: Eur Respir J 2015; 46: 405-413
Year: 2015



Subcutaneous treprostinil: a new therapeutic approach for idiopathic paediatric pulmonary hypertension
Source: Annual Congress 2009 - Pulmonary arterial hypertension
Year: 2009


Safety and long-term efficacy of transition from sildenafil to tadalafil due to side effects in patients with pulmonary arterial hypertension
Source: International Congress 2014 – Modern approach and old dilemmas in lung diseases
Year: 2014

Safety of long-term sildenafil 20 or 80 mg TID in patients with pulmonary arterial hypertension (PAH)
Source: Annual Congress 2010 - Pulmonary circulation II
Year: 2010

Long-term continuous subcutaneous treprostinil therapy for pulmonary arterial hypertension (PAH)
Source: Eur Respir J 2003; 22: Suppl. 45, 461s
Year: 2003