Secreted mediators from induced pluripotent stem cells (iPSc) attenuate fibrosis in bleomycin injured rat lung

A. Gazdhar, I. Grad, M. Gugger, A. Feki, T. Geiser (Bern, Geneva, Fribourg, Switzerland)

Source: Annual Congress 2012 - Stem cells and progenitors in injury and repair
Session: Stem cells and progenitors in injury and repair
Session type: Oral Presentation
Number: 3098
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Gazdhar, I. Grad, M. Gugger, A. Feki, T. Geiser (Bern, Geneva, Fribourg, Switzerland). Secreted mediators from induced pluripotent stem cells (iPSc) attenuate fibrosis in bleomycin injured rat lung. Eur Respir J 2012; 40: Suppl. 56, 3098

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Modified mesenchymal stem cells attenuate bleomycin induced lung injury in the rat
Source: Annual Congress 2010 - Stem cells and growth factors in lung injury
Year: 2010

Rescue of murine silica-induced lung injury and fibrosis by human embryonic stem cells
Source: Eur Respir J 2012; 39: 446-457
Year: 2012



Adrenaline stimulated mesenchymal stem cells modulate inflammation in lipopolysaccharide induced lung injury
Source: Annual Congress 2012 - Stem cells and progenitors in injury and repair
Year: 2012


Protective roles of paracrine factors of bone marrow mesenchymal stem cells in bleomycin induced lung epithelial cell injury in vitro and pulmonary fibrosis in vivo
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010


Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury
Source: Eur Respir J, 59 (1) 2004216; 10.1183/13993003.04216-2020
Year: 2022



Human mesenchymal stem cell exosomes attenuate inflammation of lung epithelial cells through miR-223 in acute lung injury
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

LSC Abstract – Network analysis of induced pluripotent stem cells secretome reveales its anti fibrotic action in rat lung injury model
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016


Successful transplantation of rat mesenchymal stem cells, for the therapy of bleomycin induced lung injury
Source: Annual Congress 2010 - Determinants of acute lung injury and fibrosis
Year: 2010

Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating hypoxic signaling
Source: International Congress 2015 – The multiple facets of stem and progenitor cells in lung health and disease
Year: 2015



Extracellular vesicles derived from mesenchymal stem cells prevent pulmonary vascular dysfunction induced by lipopolysaccharide (LPS).
Source: International Congress 2018 – Experimental research in pulmonary hypertension
Year: 2018

Using induced pluripotent stem cells to model the human lung alveolar epithelium
Source: International Congress 2018 – Pathophysiology of the human lung alveolus
Year: 2018

Mesenchymal stem cell based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysacharride in mice
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008

Mesenchymal stem cells isolated from fibrotic human lung tissue inhibit collagen expression by lung fibroblasts
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

LSC - 2021 - Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: Virtual Congress 2021 – In vitro modelling of lung disease: reach out to the next dimension
Year: 2021


Reduction of lung injury and fibrosis by human embrionic stem cells in a mouse model of silica-induced lung fibrosis
Source: Annual Congress 2011 - Experimental models and research in diffuse parenchymal lung diseases
Year: 2011

Pulmonary transplantation of human induced pluripotent stem cell-derived macrophages
Source: International Congress 2019 – Airway regenerative medicine: from bench to bedside
Year: 2019


PP206 – Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: ERS Lung Science Conference 2021
Year: 2021

Characterization of human mesenchymal stem cells phenotype and secretome in a in vitro model of acute lung injury inflammation
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011

The secretome of induced pluripotent stem cells (iPSC) modulates macrophage phenotype in the fibrotic lung
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015