Early oxygen desaturation is related to acute mountain sickness (AMS) development during acute high altitude (HA) exposure
G. Mandolesi, L. Pomidori, G. Avancini, E. Bernardi, M. Bartesaghi, A. Cogo (Ferrara, Milan, Italy)
Source: Annual Congress 2012 - Various issues in clinical physiology
Session: Various issues in clinical physiology
Session type: Thematic Poster Session
Number: 3802
Disease area: Sleep and breathing disorders
Abstract Early oxygen desaturation during HA exposure (both in the field and during HA simulated test) has been reported to be significantly related to AMS development.Aim Aim: monitor oxygen saturation (SpO2 ) and AMS during the ascent from Alagna (1200m) to Capanna Regina Margherita (4559m) with an overnight stay in Gnifetti Hut (3647m).Methods 66 subjects (55M, 18-67 yrs), intending to climb M. Rosa, were recruited at the cable care station in Alagna, equipped with a 24-h data memory pulse oximeter (Pulsox-3Si, Minolta) and asked to fill the Lake Louise questionnaire for AMS diagnosis. 25 subjects (37.8%) showed a LL score ≥3 (AMS+ group), 41 were in AMS-group.Results SpO2 % in AMS+ and AMS- was similar in Alagna (94.6±1.9 vs 95.1±1.2 n.s.) but lower in AMS+ during HA exposure: at 3275m, after 30-45 min. of cable car (85.5±4.1 vs 87.7±3.5,*); in Gnifetti Hut at rest (84.5±2.3 vs 86.4±2.4, **) and during the night (76.9±4.6 vs 79.5±3.7,*). AMS+ spent more time with lower SpO2 : time (%) at rest in Gnifetti Hut with SpO2 % <80 (15.8±13.8 vs 7.2±7.7,**) and during the night with SpO2 %<75, and <70 (33.2±32.9 vs 15±18.5, **; 11.8±19.3 vs 2.7±6.2, *). Only 34 subjects (26M) climbed to Capanna Regina Margherita (14AMS+); AMS+ maintained SpO2 % < (73.4±5.1 vs 76.8±3.8,*) and > time (hours) spent with SpO2 %<80 and 75 (3.5±1.2 vs 2.7±0.9, *; 2.5±1.4 vs 1.5±0.8,*). [* p< 0.05, ** p< 0.01]Conclusions Lower SpO2 in AMS + occurs very early at the beginning of HA exposure after 30-40 min. of ascent. Subjects which subsequently develop AMS always spend more time with SpO2 significantly lower than healthy subjects (AMS-).
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G. Mandolesi, L. Pomidori, G. Avancini, E. Bernardi, M. Bartesaghi, A. Cogo (Ferrara, Milan, Italy). Early oxygen desaturation is related to acute mountain sickness (AMS) development during acute high altitude (HA) exposure. Eur Respir J 2012; 40: Suppl. 56, 3802
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