Source: Annual Congress 2012 - The good clinical practice: useful case report
Disease area: Thoracic oncology

Abstract

Benign metastasizing leiomyoma of uterus is difficult to diagnosis extrauterine metastatic leyomyomatous lung lesion without histologic signes of malignancy.
Aim: to present a rare case of uterus leiomyoma metastasizing into the lungs that shows difficulties in diagnosis and choice of adequate treatment.
Materials and methods. The woman, 46 year, was subjected to hysterectomy with uterine appendages in 2004. Through 5 years multiple masses were observed on the thorax x-ray that interpreted as lung metastases. With videothoracoscopy marginal resection of S4 on the right was performed. Histological sections were stained with hematoxylin-eosin and van Gisone. Immunohistochemical study was performed.
Results. Histological study revealed leiomyoma consisting of many small nodules of leiomyomatosis proliferation with multicellular foci, tendency to myxomatosis, and nuclear changes (polymorphism, blurred nuclear membranes, variety of chromatin content). Mitosises were absent. The histological structure of nodes removed from lungs and uterus was identical. High expression of antibodies to smooth muscle actin (SMA), expression of receptors Esr and Prs in uterine and pulmonary nodes indicated histological identity of the process that allows us to estimate changes in the lungs as metastasis. The patient was recommended hormone therapy (antiestrogen drugs in combination with tamoxifen).
Conclusion. Immunohistochemical study is necessary to determine the exact diagnosis of benign metastasizing leiomyoma of uterus with lung damage.

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Citations should be made in the following way:
I. Dvorakovaskaya, D. Dzadzua, I. Platonova (Saint Petersburg, Russian Federation). Benign metastatic leiomyoma of uterus with lung damage. Eur Respir J 2012; 40: Suppl. 56, 3506

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