Co-ordinate regulation of vectorial cytokine release and paracellular permeability from polarized bronchial epithelium challenged with double stranded RNA (dsRNA)

J. Zhang, E. Swindle, M. Hardyman, S.T. Holgate, J.E. Collins, D.E. Davies (Shanghai, China; Southampton, United Kingdom)

Source: Annual Congress 2012 - Mechanisms of asthma
Session: Mechanisms of asthma
Session type: Oral Presentation
Number: 363
Disease area: Airway diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Zhang, E. Swindle, M. Hardyman, S.T. Holgate, J.E. Collins, D.E. Davies (Shanghai, China; Southampton, United Kingdom). Co-ordinate regulation of vectorial cytokine release and paracellular permeability from polarized bronchial epithelium challenged with double stranded RNA (dsRNA). Eur Respir J 2012; 40: Suppl. 56, 363

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Alternaria fungal extracts disrupt the barrier function and induce secretion of inflammatory cytokines in airway epithelial cells
Source: Annual Congress 2010 - Epithelial cells: cell biology and role in lung disease
Year: 2010

Differential expression of the S1P transporter, Spinster homologue 2 (Spns2), in airway epithelial cells and macrophages may drive defective macrophage function in COPD
Source: International Congress 2017 – Cigarette smoke and particulate matter: basic science and clinical aspects
Year: 2017

The epithelial integrity is preserved during particle exchange across the epithelium by macrophages and dendritic cells
Source: Eur Respir Rev 2008; 17: 78-80
Year: 2008



The epithelial integrity is preserved during particle exchange across the epithelium by macrophages and dendritic cells
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


Transcellular delivery of proteins from inflammatory cells to the epithelium
Source: International Congress 2016 – Extracellular vesicles in lung disease pathogenesis
Year: 2016


Secretory leucoprotease inhibitor (SLPI) inhibits IL-8 expression induced by double-stranded RNA in airway epithelial cells
Source: Annual Congress 2008 - Airway cell biology
Year: 2008


Human airway epithelial cell stimulation causes IL-8 expression via a PKC-TACE-EGFR-MEK pathway
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


The effect of double-stranded RNA on extracellular matrix deposition in an in vitro model of the airway mucosa
Source: International Congress 2018 – Disease exacerbations from a molecular point of view
Year: 2018




dsRNA enhances eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells
Source: Eur Respir J 2005; 26: 795-803
Year: 2005



Asthmatic airway epithelial cells subjected to apical mechanical stress exhibit suppressed interferon release following viral infection
Source: International Congress 2019 – Understanding the mechanisms underlying airway diseases
Year: 2019

Interleukin-13 regulates the epithelial ion transport in lower airways in vivo
Source: Annual Congress 2010 - Epithelial cells: cell biology and role in lung disease
Year: 2010

Mechanism of epithelial Na+ channel (ENaC) inhibition by hypoxia in alveolar epithelial cells
Source: Annual Congress 2012 - New insights into airway epithelial cell physiology
Year: 2012


PPARγ agonists modulate transepithelial anion secretion in human airway epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 483s
Year: 2005

LSC - 2019 - RNA degradation is a deficient antiviral mechanism in the asthmatic airway epithelium
Source: International Congress 2019 – Mechanisms underlying respiratory infection
Year: 2019

IL-13 regulates cilia loss and localization of cp110 in human nasal epithelium
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

Dual effect of neutrophils on secretory component production by human bronchial epithelial cells
Source: Eur Respir Rev 2006; 15: 175-176
Year: 2006



Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice
Source: Eur Respir J 2010; 36: 1436-1447
Year: 2010



Regulation of secretory component production in human bronchial epithelial cells by TGF-β
Source: Annual Congress 2008 - Airway cell biology
Year: 2008


Increased expression of Lysosomal-associated membrane protein 1 (LAMP-1) found in small airway epithelium of COPD may have functional consequence and role in autophagy.
Source: International Congress 2017 – Towards personalised medicine in COPD: biological and clinical phenotypes
Year: 2017



Dynamics of translocation, binding and phosphorylation of MARCKS in airway epithelial cells; relation to mucin secretion
Source: Annual Congress 2010 - Epithelial cell biology
Year: 2010