Inhibition of elastinolytic activity in induced sputum from COPD patients and healthy controls by recombinant alpha 1-antitrypsin (rAAT) and a fusion protein, TAPI
J. R. Topping, E. J. VandenBon, R. C. Tennant, T. T. Hansel, P. J. Barnes, P. J. Barr, P. A. Pemberton, D. J. Sundin, T. D. Tetley (London, United Kingdom; Alameda, United States Of America)
Source: Annual Congress 2004 - Noninvasive approaches to measure airway epithelial cell function
Disease area: Airway diseases
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
J. R. Topping, E. J. VandenBon, R. C. Tennant, T. T. Hansel, P. J. Barnes, P. J. Barr, P. A. Pemberton, D. J. Sundin, T. D. Tetley (London, United Kingdom; Alameda, United States Of America). Inhibition of elastinolytic activity in induced sputum from COPD patients and healthy controls by recombinant alpha 1-antitrypsin (rAAT) and a fusion protein, TAPI. Eur Respir J 2004; 24: Suppl. 48, 2945
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD) Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease Year: 2003
Increased gelatinase and collagenase activity in induced sputum from COPD patients Source: Eur Respir J 2003; 22: Suppl. 45, 179s Year: 2003
A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection Source: Lung Science Conference 2015 Year: 2015
The effect of sputum processing on tumour necrosis factor (TNFα), secretory leukoprotease inhibitor (SLPI), interleukin-6 and leukotriene-B4 (LTB4 ) in chronic bronchitis and bronchiectasis Source: Eur Respir J 2001; 18: Suppl. 33, 364s Year: 2001
A phase 1B/2A study to evaluate the effect of aerosolized, recombinant alpha 1-antitrypsin (rAAT) on epithelial lining fluid (ELF) analytes in subjects with AAT deficiency Source: Eur Respir J 2005; 26: Suppl. 49, 287s Year: 2005
PUR1800 (RV1162), A novel narrow spectrum kinase inhibitor, but not Fluticasone, reduces TNFa-induced cytokine release by primary bronchial epithelial cells from healthy volunteers and COPD patients Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control Year: 2018
Proteinase 3 activity is present in sputum from subjects with alpha-1-antitrypsin deficiency (AATD) and COPD Source: Annual Congress 2012 - The smoking gun in COPD biology Year: 2012
LSC Abstract – A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects Year: 2015
Alpha-1 antitrypsin genotypes and associated inhibitory activity towards neutrophil serine proteinases, in vitro Source: International Congress 2015 – Promising novel findings in translational pulmonary research Year: 2015
Alpha-1 antitrypsin genotypes and associated inhibitory activity towards neutrophil serine proteinases, in vivo Source: International Congress 2015 – Translational research in respiratory care: new findings Year: 2015
Levels of proteinase 3 and neutrophil elastase in plasma, BAL and biopsies in COPD Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies Year: 2020
The effects of recombinant human active protein C on inflammation and NOS in sepsis Source: Eur Respir J 2005; 26: Suppl. 49, 221s Year: 2005
Secretory leucoprotease inhibitor (SLPI) inhibits IL-8 expression induced by double-stranded RNA in airway epithelial cells Source: Annual Congress 2008 - Airway cell biology Year: 2008
Increased proportion of slow decliners in patients with alpha-1 protease inhibitor (A1-PI) deficiency following treatment with A1-PI Source: International Congress 2016 – New and old therapies for chronic lung diseases Year: 2016
Neutrophil activity assessed using a novel serological marker of human neutrophil elastase degraded calprotectin is elevated in patients with COPD or IPF Source: Virtual Congress 2021 – Advanced in vitro models for drug discovery Year: 2021
Measurement of tumour necrosis factor converting enzyme (TACE) activity on alveolar macrophages from healthy subjects and subjects with inflammatory lung disease Source: Eur Respir J 2002; 20: Suppl. 38, 417s Year: 2002
Anti-rhinoviral activity of soluble ICAM-1/FC fusion protein in primary airway epithelial cells from COPD patients Source: Annual Congress 2009 - Viruses and respiratory infections: prevalence and mechanisms of infection Year: 2009
Inhalation of α 1 -protease inhibitor (α 1 -Pi): influence on the protease-antiprotease balance in the epithelial lining fluid (ELF) of patients with α 1 -Pi deficiency Source: Eur Respir J 2001; 18: Suppl. 33, 249s Year: 2001
Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels Source: Eur Respir J 2002; 19: 952-958 Year: 2002
Decreased levels of secretory leucoprotease inhibitor in the pseudomonas -infected cystic fibrosis lung are due to neutrophil elastase degradation Source: Annual Congress 2009 - Airway inflammation and host defence Year: 2009