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Glasgow 2004
Monday 06.09.2004
Lung function technology: beyond the basic test
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Carboxyhemoglobin generation in conducting of the single breath diffusing capacity test
E. V. Babarskov, Y. A. Shulagin, E. V. Stepanov, A. V. Cherniack, Z. R. Aisanov, A. G. Chuchalin (Moscow, Russia)
Source:
Annual Congress 2004 - Lung function technology: beyond the basic test
Session:
Lung function technology: beyond the basic test
Session type:
Thematic Poster Session
Number:
2499
Disease area:
Pulmonary vascular diseases
Abstract
Aim. It has been shown carboxyhemoglobin (COHb) concentration increase in venous blood after the single breath diffusion capacity (DLsb) measurement in nonsmoking healthy volunteers [Graham B. et al. Am. J. Respir. Crit. Care Med. 2002, 165: 1504-1510]. Therefore the aim of the study was to estimate COHb concentration in the pulmonary capillaries and to determine its influence on the measured value of DLsb.
Methods. Mathematical modelling of the CO gas exchange was performed taking into account lung haemodynamics. Dynamic balance equations of CO and COHb in alveolar and pulmonary capillary volumes were solved by numerical method.
Results. It was found that during conducting of the SB-test at initial CO concentration equal to 0.3%, peak COHb concentration reaches 20% during first seconds and then slowly decrease to about 10% on 10th second and about 5% on 17th second of breathholding. As a result of Hb deficiency and CO backflow from COHb, measured value of DLsb is decreased approximately by 20%.
Conclusion. More correct algorithm for SB test results interpretation is needed, taking into account not only alveolar volume but pulmonary capillaries blood volume and lung hemodynamics.
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E. V. Babarskov, Y. A. Shulagin, E. V. Stepanov, A. V. Cherniack, Z. R. Aisanov, A. G. Chuchalin (Moscow, Russia). Carboxyhemoglobin generation in conducting of the single breath diffusing capacity test. Eur Respir J 2004; 24: Suppl. 48, 2499
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