Source: Annual Congress 2004 - Lung function technology: beyond the basic test
Disease area: Pulmonary vascular diseases

Abstract

Background: Assessment of cardiac output (Q) during catheterization using the Fick method requires a value of oxygen uptake at rest (VO₂). Instead of during catheterization VO₂ is often obtained at a pulmonary laboratory several days before cathetarization.The aim of this study is to show whether these VO₂ measurements at rest are reproducible with VO₂ measurements during catheterization and to what extent possible differences in VO₂ affect Q outcome.
Methods: Resting VO₂ uptake was measured in 12 patients 3-5 days before and during catheterization. Standard equipment ( Vmax Sensormedics ) was used. During both tests patients were breathing through a mouthpiece in supine position. An average VO₂ uptake was calculated over at least 4 minutes.Q was calculated by using the Fick equation: Q = VO₂ / (C_a - C_v)O₂. The variance of the mean difference between both tests was calculated. A Wilcoxon signed rank test was used to test for significance.
Result: The VO₂ intertest coefficient of variation is 12.9 % with a mean difference of 25 ml/min +/- 66 ( p= 0.32 ), resulting in a Q mean difference of 320 ml/min +/- 990 (p= 0.28) between the measurement beforehand and the measurement during catheterization.
Conclusion: Although only a small difference in VO₂ was found, this may be of clinical relevance when calculating Q by Fick equation.

Rating:

Share or cite this content

Citations should be made in the following way:
C. A. Klein, H. Groepenhoff, S. Holverda, F. Oosterveer, A. Vonk-Noordegraaf, P. E. Postmus (Amsterdam, The Netherlands). Reproducibility of resting oxygen uptake measurements and consequence for calculated cardiac output. Eur Respir J 2004; 24: Suppl. 48, 2494

Member's Comments

No comment yet.

Related content which might interest you: Prediction of individual cardiac output from measured VO2 and ventilation Source: International Congress 2018 – Innovations in equipment and their application Year: 2018 Reduced oxygen uptake efficiency slope in patients with cardiac sarcoidosis Source: Annual Congress 2012 - Limiting factors in exercise Year: 2012 Does oxygen pulse trajectory during incremental exercise discriminate impaired oxygen delivery from poor muscle oxygen utilisation? Source: ERJ Open Res, 5 (2) 00108-2018; 10.1183/23120541.00108-2018 Year: 2019 Modification of inspired oxygen fraction does not change exercise oxygen uptake measured by JAEGER® Vyntus CPX; a validation study Source: International Congress 2018 – Innovations in equipment and their application Year: 2018 Kinetics of haemoglobin oxygen saturation measured by continuous pulse oximetry during the 6 minute walking test Source: Annual Congress 2008 - Pulmonary rehabilitation for non-COPD and severe COPD; field exercise testing Year: 2008 Voxelotor, which left shifts the oxy-hemoglobin dissociation curve, improves oxygen desaturation in IPF patients during maximal exercise Source: International Congress 2019 – Exploring exercise responses in respiratory diseases Year: 2019 Oxygen uptake measured at the ventilatory threshold is a mortality marker in COPD Source: Virtual Congress 2020 – Exploring respiratory function Year: 2020 Impact of automatic oxygen titration alone or with high flows on exercise tolerance in patients with lung disease and exercise oxygen desaturation Source: Virtual Congress 2020 – New insights into evaluation and treatment of respiratory disease Year: 2020 Validation of the assessment of flow limitation at rest by overlapping of the tidal and maximal flow volume curves Source: Annual Congress 2009 - Quality control in lung function and new developments Year: 2009 Variability of oxygen saturation measurements from different pulse oximeters Source: Eur Respir J 2003; 22: Suppl. 45, 148s Year: 2003 Cardiopulmonary stress test: Desterminations of oxygen consumption, power and cardiac variables at ventilatory threshold. Correlation with values at maximal exercise in COPD Source: Annual Congress 2011 - Clinical physiology for clinical problems Year: 2011 Cardiac index by thermodilution and from non-invasive pulse pressure profiles analysis in PAH Source: Annual Congress 2012 - Pulmonary circulation: clinical diagnosis, treatment, end-points and animal models Year: 2012 Exercise oxygen uptake efficiency slope independently predicts poor outcome in pulmonary arterial hypertension Source: Eur Respir J 2014; 43: 1510-1512 Year: 2014 Discriminating features of responses in cardiopulmonary exercise testing Source: ISSN=ISSN 1025-448x, ISBN=ISBN 978-1-904097-49-5, page=36 Year: 2007