Source: Annual Congress 2004 - Lung function technology: beyond the basic test
Disease area: Airway diseases

Abstract

Nitric oxide in exhaled air (FeNO) is regarded as a readout of airway inflammation in patients with atopic asthma. Other inflammatory markers (e.g. carbonmonoxide) in exhaled air have shown to be related to lung volume. This study was performed to evaluate the correlation between FeNO, lung function and body height an weight.
Methods: In 24 healthy, non-smoking persons (m/f=10/14 age 27.9 (18-41yrs)) we measured height, weight and lung function (spirometry (PEF, FEV1,FEV1%FVC,MEF50,MEF25,MMEF25-75,FVC),body plethysmography (RV,TLC,RV%TLC), diffusion capacity (TLCO SB, TLCO/VA)). All measurements were performed using standardised devices (Masterlab, Viasys, Germany). FeNO was measured according to ATS recommendations (Niox, Aerocrine AB, Sweden).
Results: All subjects had normal lung function. We found no correlation between FeNO and any of the measured lung function parameters. However there was a significant association between FeNO and body mass index. Linear regress coefficient 1.5 ppb/kg/m², 95% confidence interval 0.5 - 2.6, p = 0.007.
Conclusion: Increase in body mass index, but not lung function, is associated with increase in FeNO. These data suggest an upregulation of pulmonary inflammatory processes in obese subjects, which might explain the association between obesity and asthma in epidemiological studies.

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Citations should be made in the following way:
I. Prins, J. M. Tersmette, K. M. Winter de - Groot de, C. K. Ent van der (Utrecht, The Netherlands). Exhaled nitric oxide is increased in obese subjects. Eur Respir J 2004; 24: Suppl. 48, 2484

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