TGFβ-induced proteoglycan production and α-smooth muscle actin expression in cultured human lung fibroblasts is inhibited by combination of budesonide and formoterol

E. Gürcan, L. Todorova, A. Miller-Larsson, G. Westergren-Thorsson (Lund, Sweden)

Source: Annual Congress 2004 - Further pharmacological and clinical evidence for using long-acting β-agonists with inhaled corticosteroids
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. Gürcan, L. Todorova, A. Miller-Larsson, G. Westergren-Thorsson (Lund, Sweden). TGFβ-induced proteoglycan production and α-smooth muscle actin expression in cultured human lung fibroblasts is inhibited by combination of budesonide and formoterol. Eur Respir J 2004; 24: Suppl. 48, 1654

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Proteoglycan production in cultured human lung fibroblasts is synergistcally inhibited by combination of budesonide and formoterol
Source: Eur Respir J 2003; 22: Suppl. 45, 286s
Year: 2003

Inhibition of IL-8 and RANTES release from cultured human airway smooth muscle cells by fluticasone and budesonide
Source: Eur Respir J 2002; 20: Suppl. 38, 384s
Year: 2002

IL-1β-induced MCP-1 production in human airway smooth muscle cells, modulation by dexamethasone, rolipram, and salbutamol
Source: Eur Respir J 2001; 18: Suppl. 33, 353s
Year: 2001

Bosentan blocks TNFα-induced GM-CSF expression in human airway smooth muscle cells
Source: Annual Congress 2008 - Basic science in asthma and COPD
Year: 2008

Budesonide and formoterol rapidly and effectively inhibit ERK1/2 phosphorylation in bradykinin-stimulated human lung fibroblasts
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008

Rapid inhibitory effects of budesonide and formoterol on bradykinin-induced Ca2+ mobilization in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Budesonide and formoterol differentially modulate the expression of C/EBP-alpha and calreticulin in airway smooth muscle (ASM) cells
Source: Eur Respir J 2006; 28: Suppl. 50, 756s
Year: 2006

Glycosaminoglycan synthesis is modulated by ciclesonide in human lung cells
Source: Eur Respir J 2004; 24: Suppl. 48, 346s
Year: 2004

Theophylline at the therapeutic concentrations abrogate decreased smad7 expression in cultured smooth muscle cells stimulated with LTD4 and EGF
Source: Eur Respir J 2005; 26: Suppl. 49, 25s
Year: 2005

Inhaled budesonide induces corticosteroid-dependent gene expression in asthmatics: Validation in primary epithelial and airways smooth muscle cells
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011


Combination of budesonide and formoterol is more effective in inhibiting GM-CSF production by bronchial epithelial cells than either drug alone
Source: Eur Respir J 2003; 22: Suppl. 45, 457s
Year: 2003

Effect of beclomethasone dipropionate, formoterol and their combination on TNF-α-induced ICAM-1 and IL-8 expression in human bronchial epithelial cells
Source: Annual Congress 2012 - Molecular biology of pro- and anti-inflammatory responses in the lung
Year: 2012

Effects of TGF-beta and budesonide on MAPK phosphorylation, IL-6/IL-11 secretion, and cell proliferation in human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 662s
Year: 2006

Comparison of gene expression profiles of IL-1β stimulated normal lung fibroblast and bronchial smooth muscle cells
Source: Eur Respir J 2006; 28: Suppl. 50, 104s
Year: 2006

Inhibitory activity of fluticasone propionate (FP) and salmeterol (SAL) on TGF-β–induced expression of α-smooth muscle actin (α-SMA) by human primary airway fibroblasts (Fbs)
Source: Annual Congress 2003 - Cell signalling and cytokines in asthma
Year: 2003


Formoterol and salmeterol enhance cytokine release in primary bronchial epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 101s
Year: 2004

Downregulation of vascular adhesion molecule (VCAM)-1 expression by nasal fibroblasts by levocetirizine in vitro
Source: Eur Respir J 2004; 24: Suppl. 48, 129s
Year: 2004

Downregulation of TNF-α induced E-selectin expression by beclomethasone dipropionate and formoterol in human endothelial cells
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010

Fluticasone and salmeterol downregulate in vitro, fibroblast proliferation and ICAM-1 or H-CAM expression
Source: Eur Respir J 2001; 18: 139-145
Year: 2001



Dexamethasone and formoterol modulate human rhinovirus induced MMP-9 expression
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010