Bioconductance as adjunctive technique for evaluation of patients with lung masses detected by chest CT
K. Callahan, R. Yung, M. Y. Zeng, M. Garff (Salt Lake City, Baltimore, United States Of America)
Source: Annual Congress 2011 - Innovative diagnostic methods for lung cancer
Session: Innovative diagnostic methods for lung cancer
Session type: Oral Presentation
Number: 4502
Disease area: Thoracic oncology
Abstract Introduction: CT screening may reduce LC mortality in high risk subjects but also find many masses with indeterminate features resulting in invasive procedures for benign lesions.Aims: We hypothesize that trans-thoracic bioelectrical conductance measurements may discriminate benign from malignant CT-detected lesions.Methods : 41 subjects with CT-detected masses and or lung cancer symptoms such as cough, hoarseness, dyspnea, hemoptysis, weight loss or recurrent respiratory infections enrolled. Prior to biopsy, measured 9 parameters at 62 sites were conducted with Bioconductance Scan Platform (BSP). For each subject a composite score from collected data was calculated and an optimal cut-point set to discriminate between the malignant and benign outcomes selected.Results: 26 pathology-confirmed NSCLC, 2 SCLC, 1 carcinoid whereas 12 had a benign outcome based on pathology(9) or stable follow-up CT(3). BSP data for LC cases: 26 true positives, 3 false negatives (including the carcinoid), 90% sensitivity. For benign cases, the BSP resulted in 1 false positive,11 true negatives, 92% specificity. The overall ROC from BSP analysis was 91%.
Conclusion: BSP bioconductance measurements is associated strongly with a thoracic cancer or benignity. A technology that non-invasively provides adjunctive information to CT scanning to decide whether biopsy or further follow-up is appropriate will be an important clinical tool.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
K. Callahan, R. Yung, M. Y. Zeng, M. Garff (Salt Lake City, Baltimore, United States Of America). Bioconductance as adjunctive technique for evaluation of patients with lung masses detected by chest CT. Eur Respir J 2011; 38: Suppl. 55, 4502
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you: