Source: Annual Congress 2011 - The ageing pulmonary interstitium
Disease area: Paediatric lung diseases

Abstract

Actuality. Respiratory disorders accompanied by endothelial disorders, but the clinical significance of changes in rates which characterize endothelial function in neonatology is neglected, because the purpose of our study was to establish clinical significance of endothelial dysfunction in preterm infants with respiratory disorders by the value of serum vascular endothelial growth factor (VEGF).
Materials and methods. The main group 67 children, who at birth had diagnosed respiratory distress syndrome. The average birth weight 1473,1±97,4 g, gestational age - 29,9±0,6 weeks. In the controling group were included 20 premature infants with birth weight 1529,5±82,8 g and gestational age 30,6±0,6 weeks without respiratory disorders.
Results and discussion. The values of serum VEGF at 5-7 day of life in children of all investigated groups did not differ significantly (by 124,9±31,9 and 135,8±32,2 pg/ml, p>0,05). In dynamics, 28 day life, we set the negative trend in the core group of children (114,1±24,5 to 328,8±92,3 pg/ml in the comparison group, p<0,05). Regression analysis established the relationship between values of serum VEGF at 5-7 day of life and indicators of body weight (r=0,62, p<0,05), duration of gestation at birth (r=0,64, p<0,05) and duration of mechanical ventilation (r=0,89, p<0,05)
Conclusions. The low value of VEGF for 5-7 day of life in preterm infants with respiratory failure and lack of growth in the dynamics indicate low ability to restore damaged capillaries and the risk of chronic disease.

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Citations should be made in the following way:
O. Mazulov, Y. Kyslova, O. Yablon (Vinnitsa, Ukraine). Endothelial dysfunction in preterm infants with respiratory disorders. Eur Respir J 2011; 38: Suppl. 55, 797

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