Source: Annual Congress 2011 - Role of the biomarkers in airway diseases
Disease area: Airway diseases

Abstract

Background: NMR metabonomic of EBC significantly divide healthy from COPD patients, identifying specific profiles linked to cellular oxidative pattern.Curcumin is a recognized anti-oxidant agent in biochemical cellular balance.As it is still unknown if the pattern recognized by NMR metabonomic spectroscopy in COPD is sensitive to exogenous nutrients, in this preliminary open label study we evaluated the effect of daily oral administration of an herbal preparation containing high dosage of curcumin (HPC) on EBC in COPD patients. Materials and Methods: 10 COPD (8 M, age 63.3 ± 7.9) were evaluated at baseline (T0) and after 12 weeks (T1) of oral administration of HPC once a day collecting each visit EBC, clinical score (BSCN) and spirometry.Results: EBC collected from each patient (T0 and T1) were different in NMR spectra profiles and in comparison with spectra of a HPC. Notably, a completely different profile is observed in T1 patients, with many new resonances appearing. Moreover, 2 patients examined two months after T1 demonstrated EBC profiles similar to those at baseline.

Among clinical parameters BSCN score was 4.9 ± 0.9 at T0 and 7.5 ± 1.0 at T1, while FEV1 values resulted slightly but not significantly increased at T1. Conclusions: NMR metabonomic is a sensitive method to explore nutriceutic effects of exogenous antioxidant on EBC in patients affected by COPD.

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G. de Laurentiis, G. Scapagnini, D. Paris, D. Melck, M. Maniscalco, A. Motta, S. Matteo, A. Bianco (Naples, Campobasso, Pozzuoli, Somma Vesuviana, Italy). NMR EBC metabonomic to assess the nutricecutic effect in COPD. A pilot study of oral administration of a curcumin based herbal preparation. Eur Respir J 2011; 38: Suppl. 55, 4793

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