Source: Annual Congress 2011 - Physiology of human pulmonary hypertension
Disease area: Pulmonary vascular diseases

Abstract

Background: A resting heart rate (RHR) over 70 bpm is associated with increased mortality in left heart failure. We investigated the prognostic value of RHR in pulmonary arterial hypertension (PAH).
Methods: We related RHR during baseline right heart catheterisation from PAH-patients to their characteristics and outcomes.
Results: Data from 126 PAH (84 females, age 52±17y, 70 idiopathic, 27 collagen vascular, 12 congenital heart, 13 HIV, 4 portopulmonal) catheterised from 2000 to 2010 were analysed. Patients were in NYHA II/III/IV (18/67/41), mean 6MWD 384±122 m, RHR 82±14 bpm, mPAP 49±17 mmHg, PVR 826±470 dyn*s*m-5, the mean follow-up was 46±35 month under optimal medical treatment. Patients with a RHR ≤ 70 bpm had a lower PVR 664±384 vs 887±487 dyn*s*m-5 but did otherwise not defer from a RHR > 70bpm. 76% of patients with a RHR ≤ 70 bpm were alive after 58±37 months compared to 60% with a RHR > 70 bpm.

Conclusion: In this cohort we found that baseline RHR might be prognostically important in PAH. The role of RHR in PAH and whether reducing RHR in in analogy to left heart failure should be analysed in larger cohorts.

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Citations should be made in the following way:
S. Ulrich, G. Suna, L. Huber, U. Treder, R. Speich (Zurich, Switzerland). A lower resting heart rate may be prognostically favourable in pulmonary arterial hypertension. Eur Respir J 2011; 38: Suppl. 55, 2312

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