Source: Annual Congress 2011 - Tuberculosis in immunocompromised hosts
Disease area: Respiratory infections

Abstract

Background: Tuberculosis and HIV infection are two serious problems, which associated condition is one another negative. In Romania there is an increased prevalence of tuberculosis, but proportion of TB-HIV coinfected patients remains low. Due to management issues in this group of patients, bacteriological identification and susceptibility profile are very important.
Aims: To identify the bacteriological profile of strains isolated from new cases of TB-HIV patients and to evaluate the management in this group of patients.
Methods: Descriptive retrospective analysis of new cases of TB-HIV coinfected patients reported in 2009 in the National Register of Tuberculosis.
Results: Were analyzed 155 patients (70.8%) representing the new cases from a total of 219 TB patients notified as seropositive. The mean age was 28 years, 68.3% males, most of them with pulmonary TB (127 patients, representing 81.9% of total cases). Bacterial confirmation rate in culture was low (48.3%), even in pulmonary TB cases (69 patients). Drug resistance was certified in six cases: monoresistance to rifampicin in one case and MDR in 5 cases. Among the patients of our group 114 were successfully treated, 10 patients abandoned TB treatment and 6 failed. The mortality rate was 11.6% (18 patients), most of deceases in pulmonary TB cases (83.33%).
Conclusions: We found a low rate of drug resistance in our group, but bacteriological confirmation was possible only in 48,3% cases. Intensified efforts in bacteriological examinations are necessary to confirm the TB in HIV patients and to exclude other pathology, for a appropriate management.

Rating:

Share or cite this content

Citations should be made in the following way:
M. Dede, C. Tudose, I. Pele, L. Lihatchi, E. Ibraim (Bucharest, Romania). Bacteriological profile in new cases of TB-HIV coinfected patients in Romania. Eur Respir J 2011; 38: Suppl. 55, 1933

Member's Comments

No comment yet.

Related content which might interest you: TB situation in Bulgaria – epidemiology, TB-HIV co-infection Source: Eur Respir J 2006; 28: Suppl. 50, 16s Year: 2006 Tuberculosis for HIV infected patients in Latvia Source: Eur Respir J 2001; 18: Suppl. 33, 314s Year: 2001 Consideration about chemoresistant TB incidence at HIV infected children in Romania Source: Annual Congress 2008 - Epidemiology and clinical management of multidrug-resistant and extensively drug-resistant tuberculosis Year: 2008 The peculiarities of histological diagnostic of tuberculosis (TB) in HIV-infected patients in Ukraine Source: Eur Respir J 2006; 28: Suppl. 50, 20s Year: 2006 Safety of bedaquiline for treatment of MDR/XDR tuberculosis in HIV co-infected patients Source: International Congress 2019 – Extra-pulmonary tuberculosis and comorbidities Year: 2019 HIV seroprevalence among tuberculosis patients in Tripoli Libya Source: Eur Respir J 2004; 24: Suppl. 48, 197s Year: 2004 Treatment outcomes of MDR-TB and HIV co-infection in Europe Source: Eur Respir J, 49 (6) 1602363; 10.1183/13993003.02363-2016 Year: 2017 Structure of new cases of tuberculosis among HIV-infected persons in Belarus Source: Annual Congress 2008 - Tuberculosis in immigrants, disadvantaged populations, elderly, HIV-seropositives and in other risk groups Year: 2008 Clinico-radiological profile of tuberculosis in HIV seropositive patients of western Rajasthan Source: Annual Congress 2008 - Clinical epidemiology of tuberculosis Year: 2008 Immunological status of TB/HIV dual infection patients in Latvia in year 2009 Source: Annual Congress 2011 - Clinical challenges in tuberculosis Year: 2011 Clinical, immunological and epidemiological correlations of Tuberculosis / HIV Coinfection in patients Infected with HIV in Olt County in Romania between 2005-2015 Source: International Congress 2019 – Extra-pulmonary tuberculosis and comorbidities Year: 2019 Follow-up of TB cases failing or defaulting the first TB treatment, in Romania Source: Annual Congress 2012 - Non-tuberculous and tuberculous mycobacterial infections: from epidemiology to clinical findings Year: 2012 High prevalence of hepatitis C among patients with drug-resistant tuberculosis and its impact on the treatment outcome in Azerbaijan prisons Source: International Congress 2015 – Screening strategies in TB Year: 2015 Multidrug-resistance tuberculosis and HIV-infected patients, the effectiveness of the treatment in Ukraine Source: Annual Congress 2010 - Tuberculosis drug resistance Year: 2010 Characteristics of tuberculosis patients co-infected with COVID-19 Source: Virtual Congress 2021 – Tuberculosis, COVID-19 and other comorbidities Year: 2021 Treatment outcome among HIV positive and HIV negative TB patients in Chandigarh, India: A retrospective cohort study Source: International Congress 2015 – Management of TB: a patient focus Year: 2015 The incidence of MDR-TB in new and retreatment cases of HIV and pulmonary tuberculosis co-infection Source: Annual Congress 2013 –Tuberculosis: clinical aspects Year: 2013 Untimely found TB cases and causes of death among patients infected with HIV/TB and with TB alone in the Leningrad region Source: Annual Congress 2010 - Tuberculosis in special populations Year: 2010 Study on TB relapses compared with new cases in Cluj, Romania Source: Eur Respir J 2001; 18: Suppl. 33, 341s Year: 2001 Particularities of tuberculosis at children hospitalized with HIV co-infection Source: Annual Congress 2009 - Tuberculosis at different age groups Year: 2009