Late endothelial progenitor cells are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels

K. Paschalaki, R. D. Starke, N. Mercado, A. M. Randi, P. J. Barnes (London, United Kingdom)

Source: Annual Congress 2011 - Novel mechanisms in COPD
Session: Novel mechanisms in COPD
Session type: Oral Presentation
Number: 4904
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Paschalaki, R. D. Starke, N. Mercado, A. M. Randi, P. J. Barnes (London, United Kingdom). Late endothelial progenitor cells are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels. Eur Respir J 2011; 38: Suppl. 55, 4904

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Increased levels of circulating endothelial progenitor cells during exacerbations of COPD
Source: Annual Congress 2007 - Biomarkers and assessment of COPD
Year: 2007



Decreased number of circulating endothelial progenitor cells in patients with emphysema
Source: Eur Respir J 2005; 26: Suppl. 49, 441s
Year: 2005

Effects of training on endothelial function and circulating endothelial progenitor cells in COPD patients
Source: Annual Congress 2008 - Pulmonary hypertension I
Year: 2008


Distinct patterns of circulating endothelial cells in pulmonary hypertension
Source: Eur Respir J 2010; 36: 1284-1293
Year: 2010



Circulating haemopoietic and endothelial progenitor cells are decreased in COPD
Source: Eur Respir J 2006; 27: 529-541
Year: 2006



Blood outgrowth endothelial cells are senescent and dysfunctional in COPD due to increased DNA damage; implications for endothelial dysfunction
Source: Annual Congress 2012 - Inflammatory mechanisms in COPD
Year: 2012

Post-COVID-19 patients show an increased endothelial progenitor cell production
Source: Virtual Congress 2021 – Insights into pulmonary embolism
Year: 2021



Circulating endothelial progenitor cells and CD45+ cells in pulmonary arteries of COPD patients
Source: Annual Congress 2010 - Pulmonary circulation II
Year: 2010

Multipotent stromal cell-derived stanniocalcin-1 reduces reactive oxygen species and promotes survival of injured A549 lung cancer cells through upregulation of uncoupling-protein 2 and induction of the Warburg effect
Source: Annual Congress 2010 - New insights into reactive oxygen species
Year: 2010


Circulating progenitor cells in COPD patients
Source: Annual Congress 2011 - Bone marrow-derived stem cells in respiratory diseases: a future therapy?
Year: 2011


Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension
Source: Eur Respir J 2011; 37: 1392-1399
Year: 2011



Endothelial progenitor cells are dysfunctional in smokers and COPD patients due to increased DNA damage and senescence
Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Year: 2013

Cell cooperation between human fibrocytes and endothelial progenitor cells during neoangiogenesis is driven by the CXCR4 pathway
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and cell biology
Year: 2012

Imbalance between circulating endothelial cells and endothelial progenitors in idiopathic pulmonary fibrosis
Source: Annual Congress 2011 - What is new in the approach to pulmonary fibrosis?
Year: 2011

Impaired angiogenic supportive capacity and altered gene expression profile of CD146 mesenchymal stromal cells isolated from hyperoxia-injured neonatal rat lungs
Source: ERS Lung Science Conference 2018
Year: 2018

Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating hypoxic signaling
Source: International Congress 2015 – The multiple facets of stem and progenitor cells in lung health and disease
Year: 2015



LSC - 2018 - Impaired angiogenic supportive capacity and altered gene expression profile of CD146+ mesenchymal stromal cells isolated from hyperoxia-injured neonatal rat lungs
Source: International Congress 2018 – Molecular and cellular determinants of the developing lung
Year: 2018

Circulating fibrocytes are increased in children and young adults with pulmonary hypertension
Source: Eur Respir J 2012; 39: 104-111
Year: 2012



Circulating fibrocytes are increased in children and young adults with pulmonary hypertension
Source: Eur Respir J 2011; 39: 104-111
Year: 2012