Source: Annual Congress 2011 - Obstructive sleep apnoea in children and adults
Disease area: Sleep and breathing disorders

Abstract

Background: Sleep disordered breathing (SDB) cause‘s significant burden. Most studies have focused on cardiovascular diseases (CVD) after a diagnose of sleep apnea (SA) or obesity hypoventilation syndrome (OHS) but the overall morbidity prior to a SDB diagnose is incompletely evaluated.
Methods: Using data from the Danish National Patient Registry (1998-2006), we identified all national patients with a diagnosis of SA (19438), or OHS (755). For every patient, we randomly selected 4 age-, sex- and socioeconomic-matched citizens from the Danish Civil Registration System Statistics. We further extracted information from the Danish Ministry of Health, Danish Medicines Agency, and National Health Security
Results: Pts with SA and OHS presented increased morbidity (p<0.01) up to more than eight years prior to a SDB diagnose of SA the most common contacts were diseases of the endocrine, nutritional and metabolic diseases ((Odds Ratio (OR) SA/OHS 4.5/4.8), nervous system: OR 4.4/5.5), respiratory system (OR: 2.9/4.0)), skin and subcutaneous tissue (OR 2.5/1-3), infections (OR 1.8/3.0), CVD (OR 1.7/1.3), genito-urinary system (OR 1.3), ear-nose and throat (OR 1.3), psychiatric diseases (OR 1.1/1.4). After a SDB diagnose, patients also presented significant morbidities and mortality. CPAP treatment reduced mortality (6.6% versus 5.5 in SA pts, 4.0% in control subjects.
Conclusion: Patients with SDB shows significant morbidities several years prior to a diagnose of SA or OHS. As early detection of SA/OHS is important for improving prognosis, SDB should be considered in patient‘s with endocrine, nutritional, metabolic, neurological, pulmonary and CVD disorders.

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Citations should be made in the following way:
P. Jennum, J. Kjellberg (Copenhagen, Denmark). Morbidity prior and after a diagnosis of sleep disordered breathing. A controlled national study. Eur Respir J 2011; 38: Suppl. 55, 3242

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