Effects of steady-state female hormones on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide

N. Nassr, A. Hünnemeyer, R. Herzog, J. Scholpp, G. Lahu (Konstanz, Germany)

Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Session: Drug delivery and pharmacokinetics II
Session type: Thematic Poster Session
Number: 3987
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Nassr, A. Hünnemeyer, R. Herzog, J. Scholpp, G. Lahu (Konstanz, Germany). Effects of steady-state female hormones on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide. Eur Respir J 2011; 38: Suppl. 55, 3987

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Effects of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2009 - New bronchodilators
Year: 2009


Effect of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Eur Respir J 2006; 28: Suppl. 50, 435s
Year: 2006

Pharmacokinetics of roflumilast and its active metabolite roflumilast N-oxide are not influenced by erythromycin
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

Pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects after a single, oral dose of 500µg roflumilast in the morning versus evening
Source: Eur Respir J 2003; 22: Suppl. 45, 102s
Year: 2003

Roflumilast and its active metabolite roflumilast N-oxide do not interact with R- and S-warfarin
Source: Eur Respir J 2003; 22: Suppl. 45, 103s
Year: 2003

The effects of multiple dosing of ketoconazole on the pharmacokinetics of a single dose ambrisentan
Source: Annual Congress 2008 - Pulmonary hypertension II
Year: 2008

Pharmacokinetics and pharmacodynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

‘Total PDE4 inhibitory activity‘: a concept for evaluating pharmacokinetic alterations of roflumilast and roflumilast N-oxide in special populations and drug-drug interactions
Source: Eur Respir J 2006; 28: Suppl. 50, 436s
Year: 2006

Pharmacokinetic characteristics of roflumilast administered in gradually increasing doses of 500μg to 1000μg are dose-linear in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 108s
Year: 2002

Roflumilast and sildenafil in healthy male volunteers: Single-dose pharmacokinetic interactions, safety and tolerability
Source: Annual Congress 2010 - Drug delivery and pharmacokinetics II
Year: 2010

Pharmacokinetic characteristics of roflumilast and its active metabolite roflumilast-N-oxide are not affected by food intake
Source: Eur Respir J 2002; 20: Suppl. 38, 109s
Year: 2002

Safety, pharmacokinetics, and pharmacodynamics of TD-8236, an inhaled pan-JAK inhibitor, following single- and multiple-ascending doses in healthy volunteers and mild asthmatics
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Pharmacokinetics and pharmacodynamics of a new beclomethasone dipropionate and formoterol CFC-free fixed combination in healthy volunteers
Source: Eur Respir J 2006; 28: Suppl. 50, 667s
Year: 2006

Pharmacokinetics of roflumilast and its active metabolite roflumilast-N-oxide in middle aged and young subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 109s
Year: 2002

Lung function, pharmacokinetics, and tolerability of indacaterol maleate and acetate in asthma patients
Source: International Congress 2019 – Clinical studies of asthma treatments
Year: 2019


Safety and pharmacokinetics of nintedanib plus sildenafil in the INSTAGE trial
Source: International Congress 2019 – Treatment and prognosis of idiopathic interstitial pneumonia
Year: 2019


The safety, tolerability, pharmacodynamics and pharmacokinetics of inhaled fluticasone furoate (FF) and vilanterol (VI) are unaffected by administration in combination
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Dose escalation study in healthy male subjects to investigate safety, tolerability and systemic exposure of orally inhaled single-doses of AP301
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Absolute bioavailability of inhaled aclidinium bromide and safety and tolerability of aclidinium bromide administered intravenously in healthy subjects
Source: Annual Congress 2010 - Bronchodilator treatment for asthma and COPD
Year: 2010


Equivalent pharmacokinetics of the active metabolite of ciclesonide when using the ciclesonide-MDI with and without a spacer
Source: Eur Respir J 2004; 24: Suppl. 48, 583s
Year: 2004