Local inhibition of IL-4 and IL-13 protects lung function in OVA mouse model
N. Stowell, M. Baumann, S. Bruckmaier, A. Cornelius, C. Kane, C. Lowenstein, K. Picha, G. Sennhauser, E. Yurkow, Z. Zhou, M. Stumpp, K. O‘Neil (Radnor, United States Of America; Zurich, Switzerland)
Source: Annual Congress 2011 - Animal models of airway inflammation
Session: Animal models of airway inflammation
Session type: Thematic Poster Session
Number: 958
Disease area: Airway diseases
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
N. Stowell, M. Baumann, S. Bruckmaier, A. Cornelius, C. Kane, C. Lowenstein, K. Picha, G. Sennhauser, E. Yurkow, Z. Zhou, M. Stumpp, K. O‘Neil (Radnor, United States Of America; Zurich, Switzerland). Local inhibition of IL-4 and IL-13 protects lung function in OVA mouse model. Eur Respir J 2011; 38: Suppl. 55, 958
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Overproduction of IL-18 in the lungs induces IL-13 and IFN-g producing CD4+ T cell in the lungs, and results in airway hyperresponsiveness in Balb/c mice Source: Annual Congress 2011 - Asthma: basic science and clinical studies Year: 2011
Transgenic mice overexpressing IL-18 display increased IL-13 in the airways but no changes of the airway hyperresponsiveness in a murine model of late-phase asthma: evidence for a dual role of IL-18 on mucosal Th1/Th2 responses Source: Eur Respir J 2002; 20: Suppl. 38, 1s Year: 2002
Overproduction of mature IL-18 induces IL-13 producing CD4+Tcells in the lungs, and results in airway hyperresponsiveness and pulmonary inflammation in Balb/c mice Source: Annual Congress 2010 - Asthma: basic science and clinical studies Year: 2010
Chemokinome characterization in human lung macrophages following stimulation with Th2-type cytokines IL-4 or IL-13 Source: Annual Congress 2012 - Update on neutrophil and macrophage function in COPD Year: 2012
Up-regulation of arginase in rat primary airway fibroblasts by IL-4 and IL-13 Source: Eur Respir J 2003; 22: Suppl. 45, 386s Year: 2003
Effectiveness of Antigen85B DNA vaccine on T-helper cells cytokines release and airway inflammation in ovalbumin sensitized mice model Source: Eur Respir J 2004; 24: Suppl. 48, 6s Year: 2004
Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation Source: Eur Respir J 2001; 18: Suppl. 33, 521s Year: 2001
IL-10 produced by CD4+ T cells is essential for the development of airway hyperresponsiveness via suppression of endogenous IL-12 Source: Eur Respir J 2005; 26: Suppl. 49, 24s Year: 2005
Regulatory role of antigen-induced IL-10, produced by Tr1 cells, in airway neutrophilia in a murine model for asthma Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation Year: 2012
Effects of HSP70 induction on IL-6 production from murine alveolar epithelial cells pre-treated with endotoxine after subsequent endotoxin challenge Source: Eur Respir J 2005; 26: Suppl. 49, 346s Year: 2005
Dose-dependent effects of muIL-13Rα2, a potent IL-13 neutraliser, on the phenotype of an acute allergic airways inflammation model in BALB/c mice Source: Annual Congress 2004 - Animal models of asthma and chronic bronchitis and their relevance in pulmonary pharmacology Year: 2004
Inflammation and remodeling modulated by anti IL17 in model of lung injury induced by elastase in mice Source: International Congress 2019 – Involvement of the environment and inflammation in pulmonary remodelling Year: 2019
Allergen immunotherapy induces a suppressor memory response that is mediated by IL-10 in a mouse model of asthma Source: Eur Respir J 2003; 22: Suppl. 45, 194s Year: 2003
Interleukin (IL-13) modulates allergen-induced airway hyperresponsiveness by a pathway independent of IL-5 or eotaxin in mice Source: Eur Respir J 2003; 22: Suppl. 45, 194s Year: 2003
Alteration of eicosanoid metabolism/signalling in IL-9 overexpressing mice and impact on lung fibrosis Source: Eur Respir J 2007; 30: Suppl. 51, 575s Year: 2007
IL-17 upregulates IL-8 release by primary bronchial epithelial cells derived from stable lung allografts Source: Eur Respir J 2004; 24: Suppl. 48, 179s Year: 2004
Modified mRNA encoding Foxp3 protects against allergic asthma in mice by rebalancing T helper cell responses through an IL-23 / IL-17A-dependent mechanism Source: Annual Congress 2012 - Treating childhood asthma Year: 2012
Comparison of transcriptional differences between IL-4Ra and IL-5 blockade in a mouse model of asthma Source: Virtual Congress 2021 – Novel insights into the pathogenesis of chronic lung diseases Year: 2021
Aerobic training decreases epithelial expression of Th2 cytokines in a murine model of allergic lung inflammation Source: Annual Congress 2007 - Towards an understanding of asthma pathogenesis - novel in vitro assays and results from animal models Year: 2007
Endotoxin-induced IL-17 release by murine T-lymphocytes: interactions with airway macrophages Source: Eur Respir J 2001; 18: Suppl. 33, 408s Year: 2001