Source: Annual Congress 2011 - Role of the biomarkers in airway diseases

Abstract

Bakground: Nasal nitric oxide (n-NO) has been suggested as a screening test for primary ciliary dyskinesia (PCD) as patients with PCD have lower n-NO levels than healthy controls. Recent studies on n-NO in PCD and secondary ciliary dyskinesia (SCD) show an overlap between these two groups.
Aim: To investigate in a pilot study if n-NO can differentiate between patients with diagnosed PCD and SCD treated at our centre.
Methods: n-NO was measured in duplicate by aspiration at 5 ml/s with NIOX Mino in 21 patients with clinically diagnosed PCD (n=12) or SCD (n=9). The electron microscopy (EM) results on brush samples from the nose were available in all subjects.
Results: Reproducibility of n-NO was good in each patient. A group of patients (n=6) had clearly low n-NO (5-69ppb) compared with the rest (216-857ppb). In the group with low n-NO there were only patients with PCD while in the group with high n-NO there were both patients with SCD and PCD, including 2 with Kartagener‘s syndrome. Regarding EM findings, the only 3 subjects with no dyneinarms were in the low n-NO while 8 subjects without structural abnormalities had high n-NO values. The relatively large group with more atypical or inconclusive results was also heterogenous with regard to n-NO levels.
Conclusion: A low n-NO value had a good positive predictive value for PCD in our material, but some PCD patients had normal n-NO levels. As structural findings on EM and n-NO appear to dissociate in some subjects, we continue to investigate all PCD and SCD patients at our centre including even functional tests of ciliary clearance, to see if n-NO correlates more to the cilia function than structural abnormalities.

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Citations should be made in the following way:
C. Krantz, A. Malinovischi, A. Hollsing, K. Alving (Uppsala, Sweden). Can nasal-NO be used to differentiate between primary and secondary ciliary dyskinesia?. Eur Respir J 2011; 38: Suppl. 55, 4782

Member's Comments

Nilsson Harriet - 28.11.2011 11:39
Very nice poster and intersting data! Harriet

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