Mesenchymal stem cells down-regulate inflammation but not airway hyperresponsiveness in experimental asthma

L. A. Mariñas-Pardo, I. Mirones-Aguilar, O. Amor-Carro, R. Fraga-Iriso, B. Lema-Costa, I. Cubillo-Moreno, M. A. Rodríguez-Milla, J. García-Castro, D. Ramos-Barbón (A Coruña, Madrid, Barcelona, Spain)

Source: Annual Congress 2011 - Asthma: basic science and clinical studies
Session: Asthma: basic science and clinical studies
Session type: Poster Discussion
Number: 3269
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. A. Mariñas-Pardo, I. Mirones-Aguilar, O. Amor-Carro, R. Fraga-Iriso, B. Lema-Costa, I. Cubillo-Moreno, M. A. Rodríguez-Milla, J. García-Castro, D. Ramos-Barbón (A Coruña, Madrid, Barcelona, Spain). Mesenchymal stem cells down-regulate inflammation but not airway hyperresponsiveness in experimental asthma. Eur Respir J 2011; 38: Suppl. 55, 3269

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

Stem cell therapy attenuates airway and lung parenchyma remodeling in a murine model of chronic allergic asthma
Source: Annual Congress 2008 - Recent advances in the treatment and pathogenesis of asthma
Year: 2008


The development of an airway hyperresponsiveness (AHR) depends on mast cells following sensitization without adjuvant
Source: Annual Congress 2006 - Cellular immunology in asthma pathogenesis
Year: 2006


Allergic early phase reactions are caused by mast cells and modulate airway hyperresponsiveness
Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Year: 2010

Interaction between epithelial cells and sub-epithelial mesenchymal cells in severe non-allergic asthma
Source: International Congress 2019 – Pathophysiology and clinical insights into severe non-allergic asthma
Year: 2019


Increased arginase activity contributes to airway remodelling in chronic allergic asthma
Source: Eur Respir J 2011; 38: 318-328
Year: 2011



Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis
Source: Eur Respir J 2012; 39: 1361-1367
Year: 2012



IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma
Source: Annual Congress 2012 - Asthma and COPD: understanding through mechanisms
Year: 2012

Mast cell generated cyclooxygenase products protect from airway hyperresponsiveness in a model of chronic asthma
Source: Annual Congress 2011 - Understanding disease and drug mechanisms
Year: 2011

Estrogen prevents airway inflammation and hyperresponsiveness in a murine model of acute allergic asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 360s
Year: 2007

PP114 – Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model
Source: ERS Lung Science Conference 2021
Year: 2021

Dendritic cells-nerve interaction in allergic airway inflammation
Source: Annual Congress 2012 - Immunologic mechanisms in COPD and asthma
Year: 2012

TNF-α negatively modulates allergen-induced airway hyperresponsiveness through γδ T cells
Source: Eur Respir J 2002; 20: Suppl. 38, 27s
Year: 2002

Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells
Source: Eur Respir J 2012; 39: 439-445
Year: 2012



ILC2s in allergic airway inflammation
Source: International Congress 2014 – Highlights from the Lung Science Conference 2014
Year: 2014



Obesity enhances allergen-induced airway inflammation in a murine model of asthma
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

Thymic stromal lymphopoietin, but not ezrin, could be an early biomarker of airway epithelial dysfunction in acute allergic asthma
Source: International Congress 2019 – Evaluation of basic science in airway diseases
Year: 2019

Estrogen prevents airway hyperresponsiveness in a murine model of allergic asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 433s
Year: 2006

Increased numbers of alveolar mast cells with an altered phenotype are linked to peripheral airway remodelling in patients with allergic asthma
Source: Annual Congress 2012 - Mechanisms of asthma
Year: 2012