Source: Annual Congress 2011 - Obstructive sleep apnoea in children and adults
Disease area: Sleep and breathing disorders

Abstract

Background: In Obstructive Sleep Apnea Syndrome (OSAS), the key role of airway inflammation is confirmed. Studies about noninvasive methods and new markers of inflammation in diagnosis and management of pediatric OSAS are increasing. 8-IsoP is an oxidative stress marker.The study of this marker in urines of children with OSAS could be promising.
Aim: to evaluate urinary 8-IsoP values in children with OSAS
Methods: twenty children (mean age 6.33 ± 2.06, M/F:12/8), with referred OSAS, underwent urinary collection at the morning after the polysomnography, sleep questionnaire, medical examination. 8-IsoP was assessed in urinary sample.
Results: according to the AHI (Apnoea/Hypopnea index) obtained from the polysomnography, we found 13 subjects (group1) with primary snoring/minimum OSAS (mean AHI 1.89 ± 1.80; mean SaO2 97.59 ± 0.59) and 7 subjects (group2) with moderate/severe OSAS (mean AHI 14.65 ± 11.09; mean SaO2 96.04 ± 2.98). The urinary 8-IsoP values is higher in Group 2 (respectively Group1:0,72 ± 0,57 ng/ml vs Group2: 2.19 ± 1.29 ng/ml, p=0.01). Moreover we found a positive correlation between AHI and urinary 8Iso-P (r= 0,5; p=0,02). The linear regression analysis, performed using as dependent variable values of urinary 8-Isop and as independent variables severity of OSAS, age, sex, AHI, SaO2, Prick test, BMI percentile, adenotonsillar ipertrophy, showed that the severity of OSAS was the only predictor for levels of urinary 8-Isop (R Square: 0.415).
Conclusion: our data show that values of urinary 8-IsoP are related to OSAS severity. Further studies are needed to assess the utility of urinary 8-Isop as marker of inflammation likely due to oxidative stress.

Rating:

Share or cite this content

Citations should be made in the following way:
S. Bonafoni, S. Fedeli, V. Negro, M. C. Supino, M. C. Paolino, R. Castaldo, M. Cecili, M. Simmaco, M. P. Villa (Rome, Italy). Oxidative stress in children with OSAS: Role of urinary 8-isoprostane. Eur Respir J 2011; 38: Suppl. 55, 3240

Member's Comments

No comment yet.

Related content which might interest you: Oxidative stress in children with OSAS: 8-isoprostane values comparison in urine and exhaled breath condensate (EBC) Source: International Congress 2015 – To treat or not to treat? Sleep-disordered breathing II Year: 2015 Overnight urinary isoprostane levels during CPAP withdrawal as a marker of oxidative stress Source: International Congress 2016 – Effects of hypoxia and sleep apnoea on the lung, heart, and vessels Year: 2016 Oxidative stress in patients with asthma Source: Eur Respir J 2001; 18: Suppl. 33, 43s Year: 2001 Evaluation of 8-isoprostane as a biomarker of oxidative stress in children with obstructive sleep apnea syndrome Source: Annual Congress 2012 - Sleep monitoring, lung function and inflammation in childhood Year: 2012 Overnight urinary isoprostanes as a marker of oxidative stress in obstructive sleep apnoea Source: Eur Respir J , 49 (2) 1601787; DOI: 10.1183/13993003.01787-2016 Year: 2017 Oxidative stress and inflammation in COPD and healthy subjects Source: Annual Congress 2009 - Mechanisms of pulmonary inflammation and fibrosis Year: 2009 Oxidative stress in obese children with sleep-disordered breathing Source: Annual Congress 2011 - Obstructive sleep apnoea: clinical aspects I Year: 2011 Exhaled 8-isoprostane, a marker of oxidative stress, is increased in patients with bronchiectasis Source: Eur Respir J 2001; 18: Suppl. 33, 248s Year: 2001 Oxidative stress after withdrawal of CPAP for OSA Source: International Congress 2015 – A bout de souffle: hypoxia and sleep-disordered breathing Year: 2015 Exhaled breath condensate: Measuring inflammation and oxidative stress in preterm infants Source: International Congress 2016 – Origins of infant pulmonary disease: early pointers for identifying infants at risk and ways to improve their care Year: 2016 Oxidative stress, antioxidant and clinical symptoms in childhood asthma Source: Eur Respir J 2006; 28: Suppl. 50, 482s Year: 2006 Oxidative stress and autoimmunity in COPD Source: Annual Congress 2010 - Airway cells as targets for anti-inflammatory drugs Year: 2010 Biomarkers of oxidative stress in smokers Source: Eur Respir J 2001; 18: Suppl. 33, 218s Year: 2001 Exercise-induced oxidative stress in patients with COPD Source: Eur Respir J 2003; 22: Suppl. 45, 552s Year: 2003 Oxidative stress in obese and nonobese patients with and without asthma Source: Annual Congress 2012 - Environmental exposure and other risk factors for airway diseases Year: 2012 Oxidative protein damage in childhood asthma Source: Eur Respir J 2003; 22: Suppl. 45, 316s Year: 2003 Oxidative stress and airway inflammation in healthy smokers and COPD patients Source: Eur Respir J 2002; 20: Suppl. 38, 95s Year: 2002 Oxidative stress indicators in patients with an exacerbation of COPD Source: International Congress 2018 – Functional genomics and COPD: new challenges Year: 2018 Role of oxidative stress in susceptibility to COPD in smokers: a meta-mining study Source: Annual Congress 2009 - Genetics in the smokers corner: from inflammation in smokers via COPD to cancer Year: 2009 Dietary modulation of oxidative stress levels in COPD patients Source: Annual Congress 2009 - Exacerbations and characteristics of COPD Year: 2009