Source: Annual Congress 2011 - Role of the biomarkers in airway diseases

Abstract

Today an increasing interest is being generated by the study of lung cancer markers in the exhaled breath condensate as this sample seems to lend itself to lung cancer early-screening and follow-up. Ferritin and SOD have recently been recognized to play a role in lung cancerogenesis and patients‘ survival.
Purpose: The aim of this study was to evaluate the clinical value and the prognostic power of exhaled ferritin and exhaled SOD in lung cancer patients.
Material and methods: 40 NSCLC patients and 15 controls were enrolled in the study. All subjects under study underwent exhaled breath condensate collection and analysis of ferritin and SOD. A total of 36 patients were either given a follow-up of at least 102 weeks, or were followed up until death.
Results: Exhaled ferritin and SOD resulted higher in NSCLC than in controls and influenced by the stage of cancer. A pronounced survival difference was found in the presence of exhaled ferritin 300 ng/ml and exhaled SOD >13.5 U/µl.
Conclusions: In conclusion, although results need to be confirmed on a larger population, we supposed that the measure of ferritin and SOD in the EBC could be clinically suggested in the monitoring of lung cancer and as an outcome predictor.

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Citations should be made in the following way:
G. E. Carpagnano, A. Koutelou, A. Depalo, L. Bergantino, C. Ruggeri, D. Lacedonia, M. P. Foschino Barbaro (Foggia, Italy). Could exhaled ferritin and SOD be used as markers for lung cancer and prognosis prediction purposes?. Eur Respir J 2011; 38: Suppl. 55, 4787

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