Rapid reversal of radiation-induced murine pneumonitis by treatment with the anti-CTGF monoclonal antibody FG-3019

K. Lipson, U. Wirkner, M. Sternlicht, T. Seeley, S. Bickelhaupt, P. Peschke, P. Huber (San Francisco, United States Of America; Heidelberg, Germany)

Source: Annual Congress 2011 - Experimental models and research in diffuse parenchymal lung diseases
Session: Experimental models and research in diffuse parenchymal lung diseases
Session type: Thematic Poster Session
Number: 668
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Lipson, U. Wirkner, M. Sternlicht, T. Seeley, S. Bickelhaupt, P. Peschke, P. Huber (San Francisco, United States Of America; Heidelberg, Germany). Rapid reversal of radiation-induced murine pneumonitis by treatment with the anti-CTGF monoclonal antibody FG-3019. Eur Respir J 2011; 38: Suppl. 55, 668

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
Source: Eur Respir J, 57 (5) 2002536; 10.1183/13993003.02536-2020
Year: 2021



Impact of age on the efficacy of anti-IL-5 monoclonal antibodies in severe asthmatics
Source: International Congress 2019 – Treatment of asthma with monoclonal antibodies
Year: 2019

Anti-CTGF antibody attenuates silica-induced lung fibrosis in rats
Source: International Congress 2018 – CTD-ILD and hypersensitivity pneumonitis: from the bench to the bedside
Year: 2018



Change of lung function in severe eosinophilic asthma undergoing treatment with anti-interleukin-5 monoclonal antibody
Source: International Congress 2018 – Role of IgE and interleukin (IL)-5 in Th2-cell signatures
Year: 2018

Effects of anti-M1 prime monoclonal antibody, MEMP1972A following allergen challenge in patients with mild asthma
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

Dual inhibition of Angiopoietin-2 and VEGF-A with a monoclonal antibody improves pulmonary capillary leakage in murine experimental sepsis
Source: International Congress 2019 – ECMO, ECCO2R and other rescue therapies in acute respiratory failure
Year: 2019

The association of serum IgG antibody with symptoms of hypersensitivity pneumonitis
Source: Eur Respir J 2006; 28: Suppl. 50, 675s
Year: 2006

Phase 1 study of a novel, prolonged-action anti-IL-5 monoclonal antibody in asthma
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Efficacy of inhaled anti-IL-13 mAb in a mouse model of asthma
Source: Annual Congress 2011 - Experimental modulation of airway inflammation
Year: 2011

Efficacy and safety of anti-PD-L1 antibody in NSCLC patients who previously treated with anti PD-1 antibodies
Source: International Congress 2019 – Treatment of lung cancer
Year: 2019


The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma
Source: Eur Respir J 2001; 18: 45-52
Year: 2001



Preclinical development of an IL-13 neutralising antibody, CAT-354, for the treatment of human asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 367s
Year: 2005

Subcutaneuous injection of monoclonal antibody anti-DEC205 conjugated with ovalbumin atenuates allergic lung inflammation of animals previously sensitized to allergen
Source: Annual Congress 2012 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2012

Treatment with omalizumab (rhuMAb-E25), a monoclonal anti-IgE antibody induces effective changes in subjects with allergic asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 37s
Year: 2001

Reversing the suppression of T-cells: the role of monoclonal antibodies
Source: International Congress 2015 – Stop immune tolerance in lung cancer!
Year: 2015



Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena
Source: Eur Respir J, 56 (4) 2000117; 10.1183/13993003.00117-2020
Year: 2020



FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in idiopathic pulmonary fibrosis
Source: Eur Respir J 2016; 47:1481-1491
Year: 2016



Long-term treatment with monoclonal antibodies anti-IgE in severe asthma: Follow-up of ten patients
Source: Annual Congress 2011 - Allergen immunotherapy and anti-immunoglobulin E
Year: 2011


Comparison of anti-IL-9 and anti-IL-5 treatment efficacy in a mouse model of airway eosinophilic inflammation
Source: Eur Respir J 2003; 22: Suppl. 45, 482s
Year: 2003

Evaluation of bronchial hyperreactivity and other functional parameters in severe asthma patients treated with anti-interleukin-5 monoclonal antibody (IL5)
Source: International Congress 2019 – Real-world experience of monoclonal antibodies in asthma
Year: 2019