Roflumilast potently inhibits CXCL1 mediated neutrophil migration in COPD patients

A. Turner, P. Fenwick, P. Barnes, L. Donnelly (London, United Kingdom)

Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Session: COPD: clinical studies and animal cell models
Session type: Thematic Poster Session
Number: 3826
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Turner, P. Fenwick, P. Barnes, L. Donnelly (London, United Kingdom). Roflumilast potently inhibits CXCL1 mediated neutrophil migration in COPD patients. Eur Respir J 2011; 38: Suppl. 55, 3826

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Inhibition of LPS-induced cytokine/chemokine production from human lung macrophages by roflumilast is enabled by autocrine PGE2
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010


Carbocisteine in vivo reduces circulating miR-21 and IL-8 in exacerbated COPD patients
Source: International Congress 2019 – COPD clinical trials: inhaled and oral therapies
Year: 2019

Ionomycin stimulates a synergistic effect of IL-8 and induced sputum on PMN chemotaxis during COPD
Source: Annual Congress 2010 - COPD and asthma: models and human studies
Year: 2010


Inhibition of LPS-induced neutrophil recruitment in the lungs correlates with modulation of neutrophil CD11b expression using the selective CXCR2 receptor antagonist SB-656933
Source: Eur Respir J 2004; 24: Suppl. 48, 218s
Year: 2004

Remifentanil attenuates LPS-induced neutrophil activation
Source: Annual Congress 2012 - Infections and sepsis in the ICU
Year: 2012

LPS-induced TLR4 expression and cytokine release is impaired in monocytes and T-lymphocytes of COPD patients
Source: Annual Congress 2008 - Novel targets in the molecular pathology of lung cancer and COPD
Year: 2008

Inhibition by roflumilast vs cilomilast of pulmonary leukocyte accumulation and TNFα release in a rat model of LPS-induced pulmonary neutrophilia
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

Increased expression of sphingosine-1-phosphate and S1PR2 are associated with attenuated macrophage phagocytosis in COPD
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Hypoxia induces IL-18 and neutrophil influx in lung parenchyma possibly mediated by MIP-2
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012

The novel phosphodiesterase 4 inhibitor CI-1044 inhibits in vitro LPS-induced TNFα production in whole blood of COPD patients
Source: Eur Respir J 2001; 18: Suppl. 33, 34s
Year: 2001

Cytokine-induced production of eotaxin-3 by human lung epithelial cells is inhibited by levocetirizine
Source: Eur Respir J 2005; 26: Suppl. 49, 98s
Year: 2005

Tiotropium enhances the inhibitory effect of the long acting β2-agonist olodaterol on the release of IL-6 and IL8 by primary human lung fibroblasts of asthma patients
Source: Annual Congress 2012 - Translational respiratory medicine in asthma and COPD
Year: 2012

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects
Source: Eur Respir J 2010; 35: 564-570
Year: 2010



Roflumilast inhibits chemokine release in animal models of COPD and asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 690s
Year: 2004

Cigarette smoke markedly inhibits the LPS-induced production of interleukin-8 in bronchial epithelial cells and consequent neutrophil migration in vitro
Source: Eur Respir J 2004; 24: Suppl. 48, 100s
Year: 2004

Effects of CXCR2 antagonists on neutrophil chemotaxis from COPD patients
Source: Annual Congress 2010 - Airway cells as targets for anti-inflammatory drugs
Year: 2010

GB001 potently inhibits PGD2 metabolite-induced DP2-mediated cell signaling and eosinophil activation
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020


Activation of PAR-2 enhances ICAM-1 expression and IL-8 release in airway epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 571s
Year: 2002

TLR-4 downregulation in COPD impairs cytokine release from monocytes and Th1-lymphocytes in response to bacterial endotoxin
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


The upregulation of CD-11B expression on circulating neutrophils by CXCL8 and the involvement of CXCR1 in COPD
Source: Eur Respir J 2006; 28: Suppl. 50, 749s
Year: 2006