Source: Annual Congress 2011 - Tuberculosis in immunocompromised hosts
Disease area: Respiratory infections

Abstract

Background: We intend to assess the frequency of adverse effects of tuberculosis treatment in HIV patients.
Methods: The study was conducted at National Tuberculosis referral center in Iran, 2005-2010 including all documented TB patients with HIV co-infected. All patients received anti-TB treatment based on National TB Program. All adverse effects (AE) observed in patients were recorded in our registry.
Results: Of the total 151 TB/HIV patients, 81 (53.6%) developed adverse effects (AE) whether major or minor. Major AE (65) included hepatitis (46), convulsion (4), thrombocytopenia (17), rash (5) that 86.2% of them had CD4<100 (p<0.001). There were no differences between uses of HAART, outcome of treatment and major AE. Other AE did not show statistical significant in our study.
Conclusion: This study showed that major adverse effects do not affect to outcome of TB treatment.

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Citations should be made in the following way:
P. Baghaei Shiva, P. Tabarsi, M. Marjani, M. R. Masjedi (Tehran, Islamic Republic Of Iran). Adverse effects of treatment in HIV-associated tuberculosis patients in Iran. Eur Respir J 2011; 38: Suppl. 55, 1940

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