Source: Annual Congress 2011 - The new clinical spectrum of lung diseases: from bronchi to pleura

Abstract

Sickle cell disease (SCD) is a common genetic disorder of hemoglobin in Bahrain with a lot of pulmonary complications either acute or chronic including its effect on pulmonary function tests (PFT). IL-6 is an inflammatory cytokine that was found to be high in serum of SCD patients. Objective: To study PFT and evaluate BAL IL-6 level in adult Bahraini patients with SCD and to correlate PFT values with BAL IL-6 and the recurrent occurrence of acute chest syndrome (ACS). Methods: Study was done on 120 subjects (2 groups): group 1 (20 healthy controls) and group 2 (100 adult Bahraini SCD patients during steady state). PFT were done to all subjects. BAL was done to 20 SCD patients and 5 control subjects to evaluate the BAL IL-6. Results: PFT was abnormal in 85% of SCD patients with restrictive pattern (60%), isolated low DLCO (17%), obstructive pattern (5%) and mixed obstructive and restrictive pattern (3%). BAL IL-6 was higher in SCD patients than in controls. In SCD patients, BAL IL-6 level had significant negative correlations with both FEV₁, FVC, DLCO, and PaO₂, with no significant correlation with TLC. There were significant positive correlations between BAL IL-6 and both age and number of ACS. There were significant negative correlations between ACS number and both FEV₁, DLCO, and PaO₂ with no significant correlation between ACS number and both TLC and RV. There were significant negative correlations between age and both FEV₁, TLC and DLCO. Conclusion: Abnormal PFT in adult Bahraini SCD patients was correlated to BAL IL-6 and number of ACS indicating that impaired lung functions in this category of patients is caused by repeated vascular occlusion and increased airway inflammation.

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Citations should be made in the following way:
A. S. Bediwy, N. Noor, M. A. Hasanein (Tanta, Egypt). Lung function disturbances and BAL IL-6 in adult patients with sickle cell disease in Bahrain. Eur Respir J 2011; 38: Suppl. 55, 488

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