Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model

Olszewska W., Ispas G., Schnoeller C., Sawant D., Van de Casteele T., Nauwelaers D., Van Kerckhove B., Roymans D., De Meulder M., Rouan M.C., Van Remoortere P., Bonfanti J.F., Van Velsen F., Koul A., Vanstockem M., Andries K., Sowinski P., Wang B., Openshaw P., Verloes R.

Source: Eur Respir J 2011; 38: 401-408
Journal Issue: August
Disease area: Paediatric lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Olszewska W., Ispas G., Schnoeller C., Sawant D., Van de Casteele T., Nauwelaers D., Van Kerckhove B., Roymans D., De Meulder M., Rouan M.C., Van Remoortere P., Bonfanti J.F., Van Velsen F., Koul A., Vanstockem M., Andries K., Sowinski P., Wang B., Openshaw P., Verloes R.. Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model. Eur Respir J 2011; 38: 401-408

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Lymphocytes mediate the anti-apoptotic effect of respiratory syncytial virus on human neutrophils
Source: Annual Congress 2007 - Bronchiolitis - genetics and immunity
Year: 2007


Respiratory syncytial virus (RSV) prophylaxis in special populations
Source: Annual Congress 2011 - Paediatric epidemiology: bronchiolitis, pneumonia, asthma and spirometry in non-respiratory conditions
Year: 2011

Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection
Source: Eur Respir J 2015; 45: 718-725
Year: 2015



Cromoglycate in the treatment of respiratory syncytial virus (RSV) bronchiolitis
Source: Eur Respir J 2001; 18: Suppl. 33, 169s
Year: 2001

Inhaled and small molecules therapeutics to fight respiratory syncytial virus infection in newborn lung
Source: International Congress 2019 – Inhaled medicines and biological therapies in the current era of systemic treatments
Year: 2019


Potential inhibitors of respiratory syncytial virus (RSV) selected from a phage displayed random peptide library
Source: Eur Respir J 2002; 20: Suppl. 38, 158s
Year: 2002

Respiratory viral agents in cystic fibrosis
Source: Annual Congress 2005 - Cystic fibrosis lung disease: pieces of the puzzle
Year: 2005


The role of viruses in chronic bronchitis and exacerbations of COPD
Source: Eur Respir Monogr 2013; 60: 68-75
Year: 2013


Abortive replication and reactivation in vitro respiratory syncytial virus (RSV) infection in palivizumab-treated HeLa cells
Source: International Congress 2016 – Viral infections in different respiratory conditions: from the bedside to the lab
Year: 2016


LATE-BREAKING ABSTRACT: Effects of a single treatment with PC786, a novel inhibitor of respiratory syncytial virus replication, on viral load and biomarkers in fully differentiated human bronchial epithelial cells
Source: International Congress 2016 – Translational research in respiratory infections
Year: 2016


Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants
Source: Eur Respir J 2014; 44: 666-674
Year: 2014



Dual infection of infants by human metapneumovirus (hMPV) and human respiratory syncytial virus (hRSV) is strongly associated with severe bronchiolitis
Source: Annual Congress 2004 - Viral bronchiolitis in children: what's new in diagnosis and treatment?
Year: 2004


The role of neutrophils in viral clearance during respiratory syncytial virus (RSV) disease
Source: Annual Congress 2013 –Pulmonary infection in children: diagnosis and long-term effects
Year: 2013



Effects of respiratory syncytial virus and adenovirus infection in cytokine expression and nuclear factor-κB activation human bronchial epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 192s
Year: 2006

Interleukin-9 in severe respiratory syncytial virus (RSV) bronchiolitis
Source: Eur Respir J 2002; 20: Suppl. 38, 17s
Year: 2002

Respiratory syncytial virus infection in childcare and hospitalized children with different respiratory disease severity
Source: Annual Congress 2006 - Virus-induced respiratory tract infection
Year: 2006


Respiratory syncytial virus
Source: Eur Respir Monogr 2016; 72: 84-109
Year: 2016


Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
Source: Eur Respir J 2002; 19: 68-75
Year: 2002



Persistence of respiratory syncytial virus replication in lung dendritic cells
Source: International Congress 2015 – Paediatric pulmonary infections
Year: 2015

Respiratory syncytial virus in adults: relationships between viral load, symptoms and lung function in an experimental infection model
Source: Annual Congress 2008 - New diagnostic methods in viral and atypical infections
Year: 2008