Source: Annual Congress 2005 - Biological and treatment aspects of tuberculosis
Disease area: Respiratory infections

Abstract

IFN-gamma(IFN-g) and TNF-alpha(TNF-a) are very important in protective immunity against mycobacterial infection.Th1 lymphocytes are main subset cells in tuberculosis. IFN-g increase activity of Th1 cells.It is suggest that IFN-g is very important role in tuberculosis.Furthermore,several studies showed that TNF-a may be involved in granüloma formation of tuberculosis.
In our study,we investigated serum TNF-a and IFN-g levels of patients with active pulmonary tuberculosis.Serum IFN-g and TNF-a levels measured in 16 patients with active pulmonary tuberculosis (Group1) and in 10 healthy control subject (Group2).Mean serum TNF-a levels were 49.39±22.07 in Group1, 8.60±5.36 in Group2. Serum IFN-g values were <0.08 in Group1, <0.10 in Group2. Group1 values were compared Group2 results by using Mann Whitney U Test. TNF-a levels in Group1 were significantly higher than Group2 (p<0.001).Although, IFN-g levels in Group1 were lower than Group2, but there was no significant statistical difference between Group1 and Group2 (p>0.05).
Our findings emphasize the significant changes in serum IFNg and particularly TNF-a levels of patients with active pulmonary tuberculosis.

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Citations should be made in the following way:
F. Sahin, F. Atabey, H. Can, S. Öztürk, A. Poluman (Istanbul, Turkey). Serum IFN-γ and TNF-α levels in pulmonary tuberculosis. Eur Respir J 2005; 26: Suppl. 49, 2913

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