Source: Annual Congress 2005 - Biological and treatment aspects of tuberculosis
Disease area: Respiratory infections

Abstract

Introduction:
There are several reports about micronutrients effects in infectious diseases. Vitamin could affect immunity system especially cell mediated immunity. In this study we evaluated them role in Immunologic profiles of pulmonary tuberculosis (TB) patients. Method:
The documented smear positive pulmonary TB patients had divided to two groups randomly. All were adult (> 15 year) and had not suffered of any accompanied immuno- depressive disease.
First group received Vitamin A, E, C and Anti-TB drugs.
Second group had no other mediations except anti-TB.
Flowcytometry for CD3, CD4, CD8, CD14, CD16+56 and HLA – DR were done before treatment and after end of 2 moths in all groups.
Data was collected and analyzed by SPSS soft ware.
Results:
35 patients divided in groups (15 in Vitamin A,E,C and 20 in control group). Mean (±SD) age were 51.4± 18.5 and 52± 18 years in case and control group respectively.(P=.97)
There were significant differences (before and after) assay in all folwcytomtric profiles in both group except in CD8, HLA-DR, CD19.
CD8 had significant differences only in case group.
HLA-Dr and CD19 had not any changes in case and control groups.
Conclusion:
Vitamin therapy with A, E and C could not alter flowcytometric Profiles in TB patients. Of course we need investigate more.

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Citations should be made in the following way:
M. Mirsaedi, S. Mohammadian, A. Ostad Rahimi, J. Baghdadchi, S. D. Mansouri, S. Shaghasempour, A. A. Velayati (Tehran, Islamic Republic Of Iran). Evaluation of vitamin A, E and C supplement therapy on immunologic profiles of pulmonary tuberculosis patients. Eur Respir J 2005; 26: Suppl. 49, 2908

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