Source: Annual Congress 2005 - Biological and treatment aspects of tuberculosis
Disease area: Respiratory infections

Abstract

The aim of this research was to compare the values of serum CA-125 in active pulmonary tuberculosis (TB), pleural TB and treated active pulmonary TB patients. In this study, 58 male patients were divided into 3 groups:
Group 1: 32 patients with active pulmonary TB
Group 2: 11 patients with pleural TB
Group 3: 15 patients with past history of treated active pulmonary TB
(They had refered to us because of sinubronchitis, bronchitis and pneumonia.)
The average values of CA-125 in the three groups were as follows:
Group 1: 76.76 ± 51.62 (U/ml)
Group 2: 50.20 ± 48.87 (U/ml)
Group 3: 23.19 ± 15.10 (U/ml)
In regard to the average CA-125 values, there was a significant statistical difference between active pulmonary TB patients and those having past history of treated active pulmonary TB. (Pvalue<0.05)
In differentiating active pulmonary TB from non-active pulmonary TB, CA-125 tumor marker has a sensitivity and specificity of 65.6% and 100% respectively at a cut-off point of 54.7 (U/ml).
According to our results the value of CA-125 tumor marker is a useful indicator in differentiating active from non-active pulmonary TB.
Key word: Pulmonary Tuberculosis, activity, CA-125.


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Citations should be made in the following way:
S. Haghighi, H. Akbarshahi, S. Mahdavi, H. Emami, M. R. Masjedi (Tehran, Islamic Republic Of Iran). Comparison of serum CA-125 levels in pulmonary tuberculosis, pleural tuberculosis and treated active pulmonary tuberculosis patients. Eur Respir J 2005; 26: Suppl. 49, 2900

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