Source: Annual Congress 2005 - Biological and treatment aspects of tuberculosis
Disease area: Respiratory infections

Abstract

Upon application of DOTS program recovery rate of patients with tuberculosis became 85 – 87%. Nevertheless, about in 15% of patients treatment fails and in the majority of cases this is due to resistance to antituberculous drugs. In order to find out the causes of treatment failure we studied distribution of HLA antigens in patients with favorable
(37 patients – I group) and unfavorable (23 patients – II group) outcomes. The study revealed that DR2 antigen of HLA DR locus was more frequent in patients of II group (65.2%), while in patients of I group it could be observed in 32.4% of cases (p<0.01). On the contrary, B8 antigen of HLA B locus was more frequent in patients of I group – 27.0% and 4.3% respectively (p<0.05). Analysis of treatment outcomes in patients – carriers and non-carriers of DR2 and B8 antigens showed that unfavorable outcome could be observed in 55.5% of patients-carriers of DR2 antigen, while in non-carriers this rate made 24.2% (p<0.01). In patients-carriers of B2 antigen treatment was effective in 90.9% of the cases while in non-carriers favorable outcome could be observed in only 55.1% of cases (p<0.002). Thus the genotype of patient in Armenian population has certain impact on the course and treatment outcome of tuberculosis.

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Citations should be made in the following way:
M. D. Safaryan, L. T. Nikolayan, D. G. Khachatryan (Yerevan, Armenia). Impact of genotype on the course of pulmonary tuberculosis in new cases patients of Armenian population. Eur Respir J 2005; 26: Suppl. 49, 2895

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