Source: Annual Congress 2010 - Influenza A (H1N1) and other viral infections: therapeutic aspects
Disease area: Respiratory infections

Abstract

Background
As of this moment, around 28000 cases of influenza have been documented in the Republic of Moldova (3,8 million population). 6548 patients were tested for 2009 H1N1 influenza by RT-PCR, and 2707 were positive. In the same period of time there were 17824 patients diagnosed with pneumonia. Many of the most severe cases were referred to our tertiary care institution from around the country.
Objective
To describe the clinical characteristics of 74 patients with pneumonia associated with 2009 H1N1 influenza admitted to our facility from November 2009 to January 2010
Methods
We observed clinical, laboratory and radiological findings in 74 patients with pneumonia associated with 2009 H1N1 influenza hospitalized in our institution from November 2009 to January 2010.
Results
All 74 patients were admitted to the ICU and 16 (21,6%) died. The mean age was 35,3 years, 62 (86,1%) patients were female and 24 (7,3%) patients had obesity. Comorbidities were present in 34 (43,2%) cases, 24 patients were pregnant. The mean durations of hospitalizations was 14 days, and the mean ICU stay was 7,4 days. 46 patients developed ARDS, and 24 required invasive mechanical ventilation. Bilateral infiltrates on chest X-ray were present in 83,7%. Chest CT (performed only in 20 patients) showed airspace consolidation and ground glass opacity in a multilobar and bilateral distribution. S. viridans was the most frequent agent isolated in cultures of sputum samples (26/40). Secondary superinfection with P. aeruginosa was documented in 15 patients.
Conclusions
Influenza 2009 H1N1 can cause severe illness including pneumonia and death. S. viridans was the most frequent documented bacterial agent, followed by isolated P. aeruginosa.

Rating:

Share or cite this content

Citations should be made in the following way:
V. Botnaru, D. Chesov, V. Brocovschii, M. Ous (Chisinau, Republic Of Moldova). Pneumonia in adults with pandemic A (H1N1) 2009 influenza in Republic of Moldova. Eur Respir J 2010; 36: Suppl. 54, 2990

Member's Comments

No comment yet.

Related content which might interest you: Pathomorphology of pandemic influenza (H1N1) in terms of the present epidemic in Ukraine Source: Annual Congress 2010 - Mechanisms of respiratory infections Year: 2010 Characteristics of hospitalised patients with 2009 H1N1 influenza in Chile Source: Eur Respir J 2010; 36: 864-869 Year: 2010 The severity of pandemic H1N1 influenza in Albania Source: Annual Congress 2010 - Pulmonary infections and sepsis Year: 2010 Influenza activity in Serbia during pandemic Source: Annual Congress 2010 - Influenza A (H1N1): epidemiology Year: 2010 Regional features of pneumonia caused by influenza during epidemics of influenza virus A (H1N1) in western Ukraine Source: Annual Congress 2010 - Influenza A (H1N1) and other viral infections: therapeutic aspects Year: 2010 The H1N1 influenza pandemy and pneumonia in Iceland 2009-2010: A one year follow up study Source: Annual Congress 2011 - Influenza A (H1N1): lessons after the epidemic Year: 2011 Evaluation of pneumonia cases due to pandemic influenza A (H1N1) Source: Annual Congress 2010 - Influenza A (H1N1): epidemiology Year: 2010 Hospitalizations from pandemic influenza (pH1N1) infections among patients with asthma in Spain Source: Annual Congress 2012 - Epidemiology of various respiratory diseases Year: 2012 Clinical presentations of complicated pandemic 2009 A H1N1 flu disease in a general hospital in Bulgaria Source: Annual Congress 2010 - Influenza A (H1N1): epidemiology Year: 2010 Pandemic influenza A H1N1 in Argentina: Statistics from the epidemiological surveillance system Source: Annual Congress 2010 - Influenza A (H1N1): epidemiology Year: 2010 Hospitalizations from pandemic influenza (pH1N1) infections among patients with COPD in Spain Source: Annual Congress 2012 - Epidemiology of various respiratory diseases Year: 2012 The comaprison of clinical characteristics and courses of pediatric patients hospitalized with pandemic influenza A (H1N1) and seasonal influenza in Korea from 2009-2011 Source: International Congress 2014 – Prevention, diagnosis and consequences of respiratory infections in children Year: 2014 Characteristics and outcome of pneumonia in patients with 2009 pandemic influenza A/H1N1. Source: Annual Congress 2010 - Influenza A (H1N1): characteristics, risk factors and prognosis Year: 2010 Pneumonia and pandemic influenza virus A (H1N1/09). Immediate and remote results Source: Annual Congress 2011 - Influenza A (H1N1): lessons after the epidemic Year: 2011 Community-acquired pneumonia during the influenza pandemic A(H1N1)pdm09 and post-pandemic period in hospitalized patients, Russia Source: Annual Congress 2012 - Viral infections and rare respiratory infections Year: 2012 Bacterial co-infections in community acquired pneumonia cases of 2009 pandemic-influenza A (H1N1) virus in Spain Source: Annual Congress 2011 - Aetiology, diagnosis and outcomes in community-acquired pneumonia Year: 2011 The influenza pandemic: 1918 compared to 2005 Source: Annual Congress 2005 - New developments in infectious disease Year: 2005 Influenza A H1N1 pneumonia: The experience of two general hospitals of Liguria Source: Annual Congress 2010 - Influenza A (H1N1): epidemiology Year: 2010 Analysis of patients with pandemic 2009 influenza A (H1N1) admitted in ICU Source: Annual Congress 2010 - Influenza A (H1N1): characteristics, risk factors and prognosis Year: 2010 Management of resistant strain of swine flu H1N1 2009 Source: Annual Congress 2010 - Influenza A (H1N1) and other viral infections: therapeutic aspects Year: 2010