The feasibility of neutrophil elastase inhibitor in the treatment of acute lung injury of post pneumonectomy patients
D. H. Kim, J. J. Hwang, K. D. Kim, J. W. Lee (Daejeon, Republic Of Korea)
Source: Annual Congress 2010 - Acute respiratory failure
Session: Acute respiratory failure
Session type: Thematic Poster Session
Number: 2283
Disease area: Respiratory critical care
Abstract Introduction The critical morbidity and mortality of post pneumonectomy patients is high due to acute lung injury (ALI). Although various intensive treatments are performed to treat ALI, the mortality could not be decreased. A neutrophil elastase inhibitor (NEI), used in the treatment of ALI with systemic inflammatory response syndrome, leads to improved lung function, reduced duration of mechanical ventilation, and a shortened stay in the intensive care unit. Objectives The purpose of this sturdy is to find out the feasibility of NEI in the treatment of post pneumonectomy ALI patients. Methods From April 2004 to May 2008, 9 patients developed ALI after pneumonectomy. Group I (n=5) had undergone conventional intensive ventilator care before November 2006, Group II (n=4) underwent NEI treatment since December 2006. We retrospectively analyzed the clinical result between two groups. Results The mean lung injury score(LIS) of post acute lung injury 1day, 2 days, 3 days, 4 days is 1.5±0.7,1.3±0.6,1.6±0.8,1.2±1.1 in group I, and 1.3±0.7, 0.7±0.9, 0.6±1.2, 0.4±0.9 in group II respectively. LIS was improved in group II. In group I, 40% (2/5) was possible to extubate, but one patient was death due to recurred respiratory failure, in group II, 75%(3/4) was possible to extubate and there was no reintubation. The 30 days mortality of group I and II is 80% (4/5),and 25%(1/4) respectively. Conclusions We can not confirmatively propose that the NEI inhibitor has the survival benefit . However, the neutrophil elastase inhibitor maybe usable to increase the lung function and survival rate in the treatment of ALI of pneumonectomy patient.
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D. H. Kim, J. J. Hwang, K. D. Kim, J. W. Lee (Daejeon, Republic Of Korea). The feasibility of neutrophil elastase inhibitor in the treatment of acute lung injury of post pneumonectomy patients. Eur Respir J 2010; 36: Suppl. 54, 2283
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