Source: Annual Congress 2010 - Pathology of lung cancer
Disease area: Airway diseases

Abstract

The anticancer immunresponse may determine the outcome of lung caner. Few data are available on how effector T, NK cells and various regulatory subsets like Treg-s, or NK T-s respond to lung cancer (LC).
Blood was drawn from 28 patients (pts – age 44 to 82, males12, females 16) suffering from non-small cell lung cancer (NSCLC, n=22) or small cell lung cancer (SCLC, n=6). Since 60% of LC pts also suffered from chronic obstructive pulmonary disease (COPD), one control group was formed from COPD pts (n=28) and another one from healthy individuals (n=28).
Activated effector T cells were determined by CD4CD45RO and CD8CD45RO positivity, the naive T cells were specified by CD4CD45RA and CD8CD45RA positivity, and the regulatory T lymphocytes by CD8FoxP3 positivity. The NKT cells were defined by Va24Vb11 (iNKT) and CD161CD3 (NKT) markers. In LC pts, the ratio of activated CD4+ effector T cells was increased and the ratio of naiv CD4+ lymphocytes was decreased, as compared to COPD or healthy groups (p<0,05). In the CD8+ subgroup, the decrease of the number of naiv T cells was observed. The ratio of regulatory T lymphocytes (CD8+FoxP3+) was significantly elevated in LC pts when compared with COPD and healthy groups (p<0,001). The numbers of iNKT and NKT cells decreased in COPD and this reached the level of LC pts, and healthy control. The level of lymphocytes subpopulations did not changed after chemotheraphy.
There was an important change of T lymphocytes subsets in LC, as effectors, CD4 cells activated, naiv, CD8 cells diminished and regulatory, suppressive T cells increased. The NKT cells also activated in COPD, but their effectivity changed in LC.

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G. Galffy, D. Bartusek, A. Cseh, A. Nagy, Z. Szarvas, R. Horvath, Z. Komlósi, B. Vasarhelyi, G. Losonczy (Budapest, Hungary). The role of regulator and effector T lymphocytes in chronic obstructive pulmonary disease and lung cancer. Eur Respir J 2010; 36: Suppl. 54, 3264

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