Source: Annual Congress 2010 - Pathology of lung cancer
Disease area: Thoracic oncology

Abstract

(Background) Nicotine, which is a major component of tobacco smoke, has been known as the principal psycoactive component to induce addiction by exerting its effects on the nicotinic acetylcholcholine receptors (nAchR) composed of alpha and beta subunits in the central nervous system. This addiction is thought to lead to the high incidence of the lung cancer through exposure to many carcinogens in the lung. Besides this, recent several reports suggested that nicotine might play another role in lung cancer by promoting in vivo the growth of cancer cells via nAcR signaling. nAchR exists in non-neural organs including lung. However, the precise mechanism how nicotine induces lung cancer remains to be elucidated.
(Methods and results) To know expression profiles, we analyzed nAchR expression by immunohistochemistry in 24 Asian (Japanese) patients‘ specimen diagnosed as lung cancer (18 adenocarcinoma, 4 Squamous cell carcinoma, 1 large cell carcinoma and 1 small cell carcinoma) by Department of Pathology in Kyushu University. Interestingly, we found out that alpha 1 subunit was significantly expressed high in comparison to alpha 7 and other subunits.
(Conclusions) Differnt from previous reports that alpha 7 might be important, we got an interesting result that alpha 1 would be also related to lung cancer. Each subunit in nAchR may have an essential and unique function in oncogenesis.

Rating:

Share or cite this content

Citations should be made in the following way:
K. Tanaka, W. Shuo, M. Takeshita, M. Izumi, K. Takayama, Y. Nakanishi (Fukuoka, Japan). Enhanced expression of nicotinic alpha-1 acetylcholine receptor in lung cancer. Eur Respir J 2010; 36: Suppl. 54, 3268

Member's Comments

No comment yet.

Related content which might interest you: Muscarinic receptors mediate up-regulation of endothelin-1 expression in human lung fibroblasts Source: Annual Congress 2010 - Regulation of airway pharmacology Year: 2010 Histamine receptors in lung cancer Source: Eur Respir J 2006; 28: Suppl. 50, 812s Year: 2006 Hypoxia-mediated alterations in adenosine receptor expression in rat lung Source: Annual Congress 2011 - Experimental pulmonary hypertension Year: 2011 Increased relaxation of immature airways to beta-2 agonists is related to the attenuated expression of postjunctional smooth muscle muscarinic M2 receptors Source: Annual Congress 2004 - Understanding the complexity of how airways are regulated Year: 2004 The antitussive effects of alpha7 (a7) nicotinic receptor agonists Source: International Congress 2017 – Novel studies on bronchodilators and cough Year: 2017 Modulation of cortical and respiratory activity by 5-HT2 receptor agonist in the rat Source: Annual Congress 2008 - Control of breathing and respiratory disorders during sleep Year: 2008 Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond Source: Eur Respir J, 56 (2) 2001610; 10.1183/13993003.01610-2020 Year: 2020 Nicotinic alpha-7 receptor stimulation (a7nAChR) inhibited NF-kB/STAT3/SOCS3 pathways in a murine model of asthma. Source: International Congress 2017 – Novel mechanisms and treatments for asthma Year: 2017 Insulin acutely potentiates M3 muscarinic receptor function in rat and human airway smooth muscle Source: International Congress 2017 – Therapeutic approaches in lung disease Year: 2017 Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis Source: International Congress 2019 – Damage and remodelling in pulmonary fibrosis Year: 2019 Expression and functional involvement of muscarinic receptor 3 (M3) in human lung fibroblasts in COPD Source: Eur Respir J 2005; 26: Suppl. 49, 121s Year: 2005 Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice Source: Eur Respir J 2008; 32: 426-436 Year: 2008 Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects Source: Eur Respir J 2008; 31: 311-319 Year: 2008 In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407 Source: Eur Respir J 2007; 30: Suppl. 51, 26s Year: 2007 Vasopressin is involved in endothelin receptor antagonist-induced fluid retention in rat. Differential effect of selective ETA and dual ETA/ETB receptor antagonists Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments Year: 2012 Potentiation effect of insulin on M3 muscarinic receptor agonist induced airway smooth muscle contraction Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets Year: 2019 Characterising the cardiovascular safety profile of inhaled muscarinic receptor antagonists Source: Eur Respir Monogr 2020; 88: 238-250 Year: 2020 Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts Source: Eur Respir J 2008; 32: 555-562 Year: 2008 Expression of endothelin receptor subtypes in different pulmonary tumours Source: Eur Respir J 2005; 26: Suppl. 49, 456s Year: 2005 Pharmacological activities of R-113281, a triple NK1 /NK2 /NK3 neurokinin receptor antagonist Source: Eur Respir J 2001; 18: Suppl. 33, 264s Year: 2001