The in-vitro pharmacology of PF-4522971 – A novel inhaled Muscarinic M3 Antagonist

S. Patel, S. Marshall, S. Summerhilll, M. Strawbridge, M. Stanley, E. Stuart, M. Trevethick, M. Yeadon, N. Clarke (Sandwich, United Kingdom)

Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Session: Regulation of airway hyperresponsiveness and bronchodilators
Session type: Thematic Poster Session
Number: 1237
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Patel, S. Marshall, S. Summerhilll, M. Strawbridge, M. Stanley, E. Stuart, M. Trevethick, M. Yeadon, N. Clarke (Sandwich, United Kingdom). The in-vitro pharmacology of PF-4522971 – A novel inhaled Muscarinic M3 Antagonist. Eur Respir J 2010; 36: Suppl. 54, 1237

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The in-vitro pharmacology of PF-3429281 – A novel inhaled dual antimuscarinic/β2 adrenoceptor agonist
Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Year: 2010

The in vitro biology of PF-00610355 – a novel β2 adrenoceptor agonist with a long duration of action
Source: Annual Congress 2009 - Models of chronic airways disease and therapy
Year: 2009

Demonstration of dual pharmacology in vivo of PF-3429281: A novel inhaled dual antimuscarinic/β2 agonist
Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Year: 2010

PF-3429281 – A novel inhaled dual antimuscarinic/β2 adrenoceptor agonist in the anaesthetised dog model of bronchoconstriction
Source: Annual Congress 2010 - Bronchodilators in airways disease
Year: 2010

Treatment of sarcoidosis – pentoxifylline
Source: Annual Congress 2009 - Pleural and parenchymal diseases
Year: 2009

Airway resistances: Raw, sRaw, sReff – Which is the best determinant of airway function?
Source: Annual Congress 2010 - Lung function from infancy to adulthood
Year: 2010


Nebulized bimosiamose – anti-inflammatory pan-selectin antagonist for the treatment of COPD
Source: Annual Congress 2009 - Treatment of airways disease
Year: 2009

PF-00610355 – an inhaled β2 adrenoceptor agonist with superior potency and duration of action (DoA) to salmeterol in the conscious dog model of bronchoconstriction
Source: Annual Congress 2009 - Models of chronic airways disease and therapy
Year: 2009

Monitoring of efficacy of therapy with monoclonal antibodies – Omalizumab – Using the Recovery-ELISA
Source: Annual Congress 2011 - Treatment strategies, systemic manifestations and biomarkers in airway diseases
Year: 2011


Differential involvement of IκB kinases α and β in asthma and COPD
Source: Annual Congress 2010 - COPD and asthma: models and human studies
Year: 2010

Adrenomedullin – a protective factor in asthma?
Source: Annual Congress 2009 - Animal models of airways inflammation
Year: 2009

Tumor nekrozis faktor-alfa blockers and tuberculosis – Analysis of the 6 years
Source: Annual Congress 2011 - Tuberculosis in immunocompromised hosts
Year: 2011

Optimization of inhalation treatment – Evaluation of influence of PNEUMOlogic® and Optimiser® spacers on aerosol particle distribution from pMDI-EB
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011


Usability evaluation of NEXThaler® versus Diskus® and Turbuhaler®
Source: Annual Congress 2012 - Trials in asthma: asthma exacerbations and severe asthma
Year: 2012

Oral glucocorticoid treatment of severe asthma – Current practice in the US
Source: Annual Congress 2010 - Aspects of severe asthma
Year: 2010


Sensitivity and specificity of airway hyperreactivity (AHR) based on methacholine challenge (MCH) tests – Comparison of sGeff with FEV1 and MEF50 as target parameter
Source: Annual Congress 2012 - Bronchial challenge as a biomarker of respiratory disease
Year: 2012



Over-reading spirometry – Man or machine?
Source: Annual Congress 2011 - Quality control in lung function and exercise-related issues
Year: 2011


Asthma medication and antibiotics – Cause or effect?
Source: Annual Congress 2010 - Paediatric respiratory epidemiology: early origins of childhood asthma
Year: 2010


EGFR – a useful biomarker?
Source: Annual Congress 2009 - Biological and clinical markers in lung cancer
Year: 2009

LungPoint® – A new approach to peripheral lung lesions
Source: Annual Congress 2010 - Tissue is mostly the issue: diagnostic and therapeutic bronchoscopy
Year: 2010