Oral administration of a new prostacyclin agonist with thromboxane synthase inhibitory activity improves bleomycin-induced lung fibrosis

A. Nakamura, K. Hamada, Y. Sakai, K. Matsumoto, H. Kimura (Osaka, Kanazawa, Japan)

Source: Annual Congress 2010 - New insights in the treatment of idiopathic pulmonary fibrosis
Session: New insights in the treatment of idiopathic pulmonary fibrosis
Session type: Oral Presentation
Number: 393
Disease area: Interstitial lung diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Nakamura, K. Hamada, Y. Sakai, K. Matsumoto, H. Kimura (Osaka, Kanazawa, Japan). Oral administration of a new prostacyclin agonist with thromboxane synthase inhibitory activity improves bleomycin-induced lung fibrosis. Eur Respir J 2010; 36: Suppl. 54, 393

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010

Effects of prostacyclin analogous iloprost trometamol on bleomisin induced pulmonary fibrosis in rats
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010

Protective effect of leukotriene receptor antagonist montelukast in bleomycin induced pulmonary fibrosis
Source: Eur Respir J 2006; 28: Suppl. 50, 669s
Year: 2006

Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin induced pulmonary fibrosis
Source: Eur Respir J 2007; 30: Suppl. 51, 111s
Year: 2007

Effect of thromboxane A2(TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 264s
Year: 2001

Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in pulmonary hypertension
Source: Annual Congress 2007 - Cellular and molecular aspects of pulmonary hypertension
Year: 2007


Inhibition by roflumilast vs cilomilast of pulmonary leukocyte accumulation and TNFα release in a rat model of LPS-induced pulmonary neutrophilia
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

Naftopidil, a selective a1 adrenoceptor antagonist, inhibits the growth of lung fibroblasts and attenuates bleomycin-induced lung fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

Esterification of iloprost enhances its protective effects on pulmonary endothelium
Source: Respiratory Failure and Mechanical Ventilation Conference 2020
Year: 2020



Inhibitory effect of PGE2 receptor subtype, EP4, in bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2007 - Mechanisms of injury and repair in fibrotic, idiopathic or infectious lung disease
Year: 2007


Effects of the NO donor molsidomine on prostacyclin synthase gene expression in rats with chronic hypoxic pulmonary hypertension
Source: Eur Respir J 2001; 18: Suppl. 33, 414s
Year: 2001

Inhibition of eosinophil migration by montelukast, a cysteinyl leukotriene receptor antagonist, through down regulation of plasmin activity
Source: Eur Respir J 2004; 24: Suppl. 48, 36s
Year: 2004

Inhibitory effects of somatostatin analogue in bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2008 - Management of idiopathic pulmonary fibrosis: what can we learn from the pathophysiology?
Year: 2008


Effects of acute nitric oxide synthase inhibition in a model of chronic airway inflammation in guinea pigs: correlation with capsaicin pretreatment
Source: Eur Respir J 2002; 20: Suppl. 38, 383s
Year: 2002

PAR-2 antagonist inhibits bleomycin-induced lung fibrosis.
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019


Anti-inflammatory activity of doxofylline and theophylline in LPS-induced lung inflammation
Source: Annual Congress 2012 - Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD
Year: 2012

Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2009; 34: 1444-1451
Year: 2009



A role of prostaglandin D2 receptor, CRTH2, on bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2008 - Understanding allergic airway inflammation with the help of animal models
Year: 2008

Abrogation of bleomycin induced inflammation and lung fibrosis by angiotensin AT1 receptor antagonist. Relevance of PGE-2 modulation
Source: Eur Respir J 2005; 26: Suppl. 49, 82s
Year: 2005

Successful transition from oral prostacyclin analogue (beraprost) to the selective endothelin receptor antagonist (sitaxsentan) therapy in pulmonary arterial hypertension
Source: Annual Congress 2007 - Pulmonary hypertension: diagnosis and treatment
Year: 2007