Source: Annual Congress 2010 - New treatments for asthma and COPD
Disease area: Airway diseases

Abstract

Background: Low dose macrolides have been shown to have immunomodulatory and anti-inflammatory effects which contribute to the therapeutic efficacy in subjects with asthma. We aimed to examine the efficacy of low dose roxithromycin in subjects with chronic, stable, mild-to-moderate asthma.
Methods: In this randomized, double-blind, placebo controlled, cross-over study, 40 subjects with stable, mild-to-moderate asthma received roxithromycin (150 mg once daily) and a matching placebo for a duration of 6 weeks each with a washout period of 3 weeks between the treatments. Asthma control test (ACT), spirometric indices and Impulse oscillometry (IOS) parameters, both before and after treatments were used to evaluate the therapeutic efficacy of the study medications.
Results: Low dose roxithromycin produced a significant improvement in ACT scores [change from baseline = 2.68 ± 3.17, (p<0.001)]. However, the placebo group also showed a significant improvement in ACT scores [change from baseline = 1.80 ± 2.83, (p=0.001)]. This was not associated with any significant improvements in spirometric indices (FEV₁, FEF_25-75%, FVC) as well as in impulse oscillometry parameters (R5, R20, R20-R5 and X5) with all p values >0.05 compared to baseline and placebo.
Conclusion:
In this randomized controlled trial, low dose roxithromycin did not demonstrate any additional significant therapeutic benefit in subjects with stable, mild-to-moderate asthma. However, more studies are required to evaluate its efficacy in chronic uncontrolled asthma.

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S. Kapoor, B. Brashier, A. Udupa, R. Pawar, R. Kodgule, S. Limaye, S. Madas, P. Pandit, B. B. Ghongane, S. Salvi (Pune, India). Therapeutic effect of low dose roxithromycin in chronic stable mild-to-moderate asthma. Eur Respir J 2010; 36: Suppl. 54, 1176

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