Source: Annual Congress 2010 - COPD: treatment and monitoring
Disease area: Airway diseases

Abstract

Introduction or background
COPD is a complex disease accepted as one of the leading reasons of premature mortality worldwide, never less it is still difficult to point out it‘s best life span prognostic factor.
Aims and objectives
The aim of the study was to find out what is the most important in predicting future exacerbations and risk of premature mortality after effective hospital treatment of COPD exacerbation.
Methods
40 consecutive patients hospitalized in Department of Pneumonology Medical University of Silesia because of COPD exacerbation were followed up. Subjects with a history of cancer were disqualified. On discharge following test were performed: spirometry, body pletysmography, diffusion capacity, trans thoracic echocardiography and whole night polisomnography. Blood was collected for routine blood count and biochemical analysis. Immunoenzymatic tests included: hs-CRP, endothelin 1 (ET-1), NT-proBNP, IL-6, TNF-alfa. Patients took part in 6MWT, and basic clinical data was collected (BORG, MRC, BMI, pack-years and age). BODE index, and creatinine klirens were also calculated. All subjects were followed up and their post hospitalization survival time as well as number of exacerbations were analyzed. Information‘s were based on phone call questionnaire and on clinical assessment during routine checkup visits.
Results
The average time from hospitalization to phone assessment was 15,1 ± 8,2 month. Multivariable analysis revealed that only pack-years (p=0,005) and 6MWT distance (p=0,03) were predictive for premature death.
Conclusions
Smoking history and exercise capacity seem to have the strongest impact in predicting probability of premature death after recovery from COPD exacerbation.

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S. Skoczynski, K. Mizia-Stec, G. Brozek, E. Sozanska, M. Ograbek-Krol, M. Tazbirek, Z. Gasior, W. Pierzchala (Katowice, Poland). Assessment of premature death risk after recovery from COPD exacerbation. Eur Respir J 2010; 36: Suppl. 54, 1322

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