Source: Annual Congress 2010 - State of the art imaging
Disease area: Airway diseases

Abstract

Introduction: Two-dimensional gamma scintigraphy (2DGS) is used for quantifying the amount of drug delivered from therapeutic inhaler devices to the lungs. The lungs are divided into central (C) intermediate (I) and peripheral (P) regions. Aim: To compare 4 methods of partitioning the lung image. Methods: Using lung deposition data for 4 mild asthmatics we calculated the P/C ratio and Penetration Index (PI). PI = P/C count rate for aerosol deposition divided by P/C count rate for a krypton-ventilation scan. Results: (Table) The lung areas of C and P regions and gamma count rate varied greatly depending on the method used but there was good agreement of PI. Conclusions: PI is least affected by how lung regions are drawn and should be the primary endpoint to compare results from different scintigraphic lung deposition studies. Care should be taken when attributing 2DGS regions to specific 3D-anatomical airway structures.

Method	P/C	PI	Region Area %		Region Count Rate %
			C	P	C	P
1	0.7	0.4	19.7	52.3	36.7	25.5
2	0.7	0.5	32.5	67.5	59.7	40.3
3	1.4	0.6	20.3	79.7	41.2	58.8
4	0.9	0.5	25.6	74.4	52.5	47.5

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Citations should be made in the following way:
M. Biddiscombe, R. Underwood, S. Meah, O. Usmani (London, United Kingdom). Gamma scintigraphy: How should we measure regional lung deposition?. Eur Respir J 2010; 36: Suppl. 54, 5279

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