The extent of exercise-induced oxidative stress is minimized by erdosteine, but not placebo, in severe COPD
R. Dal Negro, S. Tognella, C. Micheletto, M. Visconti, S. Bertacco (Bussolengo, Italy)
Source: Annual Congress 2010 - New treatments for asthma and COPD
Session: New treatments for asthma and COPD
Session type: Thematic Poster Session
Number: 1171
Disease area: Airway diseases
Abstract Erdosteine (E) has proved significant anti-oxidant and anti-inflammatory properties in COPD. Aim: as exercise induces oxidative stress, the ability of E to affect the release of pro-inflammatory mediators after exercise was investigated vs placebo (P) in severe COPD. Methods: 24 severe COPD patients (20 males; mean age=70.1y (range 58-80y); mean FEV1= 41.4% pred. (range 34-49) performed a 6-min walking test (6MWT) in basal condition and after a 10-day treatment with E 300mg bid or indistinguishable P, according to a randomised, double-blind design. ROS (Fort Units-FU) and 8-ISO levels (pg/ml) were measured in blood before and immediately after 6MWT. Absolute and % mean changes±se from bsln. were calculated in each treatment group and statistically compared (t test); p<0.05 was accepted. Results : in bsln. mean ROS levels pre-6MWT were 322.4 FU±18.9se in P and 333.9 FU±25.9se in E group (p=ns), with an increase post-test of +25.5%±4.5se and +27.5%±4.6se, respectively (p=ns). Mean 8-ISO levels were 7.9pg/ml±0.6se in P and 8.7pg/ml±0.7se in E group (p=ns), with a post-6MWT % change of +18.3%±2.9se and +16.9%±2.7se, respectively (p=ns). After a 10-day treatment, mean pre-6MWT levels of ROS and 8-ISO remained unchanged in both groups (ROS=325.1FU±17.7se and 341.7FU±21.3se; 8-ISO= 7.9pg/ml±0.6se and 8.3pg/ml±0.6se, respectively, both p=ns), while the post-6MWT % changes were significantly reduced only in the E group(ROS= +14.6%±2.7se and 8-ISO= +14.1%±2.6se, p<0.025 and p<0.006 vs placebo, respectively). Conclusions : Erdosteine 300mg bid, but not placebo, minimizes the exercise-induced oxidative stress in COPD, being its anti-inflammatory properties further emphasized.
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R. Dal Negro, S. Tognella, C. Micheletto, M. Visconti, S. Bertacco (Bussolengo, Italy). The extent of exercise-induced oxidative stress is minimized by erdosteine, but not placebo, in severe COPD. Eur Respir J 2010; 36: Suppl. 54, 1171
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